Quantitative comparison of hemodynamics in simulated and 3D angiography models of cerebral aneurysms by use of computational fluid dynamics

• Published in: Radiological physics and technology 2015-07, Vol.8 (2), p.258-265
• Main Authors: Saho, Tatsunori, Onishi, Hideo
• Format: Article
• Language: English
• Subjects: Cerebral Angiography; Hemodynamics; Humans; Hydrodynamics; Imaging; Imaging, Three-Dimensional; Intracranial Aneurysm - diagnostic imaging; Intracranial Aneurysm - physiopathology; Medical and Radiation Physics; Medicine; Medicine & Public Health; Nuclear Medicine; Patient-Specific Modeling; Radiology; Radiotherapy
• ISSN: 1865-0333; 1865-0341
• DOI: 10.1007/s12194-015-0315-4

In this study, we evaluated hemodynamics using simulated models and determined how cerebral aneurysms develop in simulated and patient-specific models based on medical images. Computational fluid dynamics (CFD) was analyzed by use of OpenFOAM software. Flow velocity, stream line, and wall shear stress (WSS) were evaluated in a simulated model aneurysm with known geometry and in a three-dimensional angiographic model. The ratio of WSS at the aneurysm compared with that at the basilar artery was 1:10 in simulated model aneurysms with a diameter of 10 mm and 1:18 in the angiographic model, indicating similar tendencies. Vortex flow occurred in both model aneurysms, and the WSS decreased in larger model aneurysms. The angiographic model provided accurate CFD information, and the tendencies of simulated and angiographic models were similar. These findings indicate that hemodynamic effects are involved in the development of aneurysms.