Skeletal muscle atrophy in advanced interstitial lung disease

Background and objective A limited number of studies examine skeletal muscle dysfunction in individuals with interstitial lung disease (ILD). We compared upper and lower limb muscle size and strength in individuals with advanced ILD with healthy controls. Second, the relationships of muscle size to...

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Bibliographic Details
Published in:Respirology (Carlton, Vic.) Vic.), 2015-08, Vol.20 (6), p.953-959
Main Authors: Mendes, Polyana, Wickerson, Lisa, Helm, Denise, Janaudis-Ferreira, Tania, Brooks, Dina, Singer, Lianne G., Mathur, Sunita
Format: Article
Language:English
Subjects:
Adult
Aged
Atrophy
Female
Humans
interstitial lung disease
Lower Extremity - pathology
Lung Diseases, Interstitial - pathology
Lung Diseases, Interstitial - physiopathology
Male
Middle Aged
muscle atrophy
Muscle Strength
Muscle, Skeletal - pathology
Muscle, Skeletal - physiopathology
Quadriceps Muscle - diagnostic imaging
Respiratory Function Tests
Ultrasonography
ultrasound
Upper Extremity - pathology
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Summary:Background and objective A limited number of studies examine skeletal muscle dysfunction in individuals with interstitial lung disease (ILD). We compared upper and lower limb muscle size and strength in individuals with advanced ILD with healthy controls. Second, the relationships of muscle size to muscle strength and function were explored. Methods Individuals with advanced ILD listed for lung transplant and healthy control subjects were studied. B‐mode ultrasound was performed to assess cross‐sectional area (CSA) of rectus femoris and thickness of gastrocnemius and soleus and biceps brachii. Subjects performed isometric muscle strength testing, Short Physical Performance Battery, Timed Up and Go, and Unsupported Upper Limb Exercise Test. Results Twenty‐six individuals with advanced ILD (61 ± 8 years; 73% males; forced vital capacity: 2 ± 0.8 L, 49 ± 13% predicted; diffusing capacity of carbon monoxide: 9.3 ± 4 mL/min/mm Hg, 51 ± 20% predicted) and 12 healthy age and gender‐matched controls (56 ± 9.5 years; 50% males) were included. Compared with controls, people with ILD had a smaller CSA of rectus femoris (7.6 ± 2.1 vs 9.4 ± 2.4 cm2; P = 0.03) and lower strength of knee extensors (119 ± 35 vs 147 ± 39 Nm; P = 0.02) and plantarflexors (37 ± 19 vs 50 ± 15 Nm; P = 0.02), but not of biceps. Individuals with ILD also had impaired performance on all functional tests (P 
ISSN:1323-7799
1440-1843
DOI:10.1111/resp.12571