Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway

Persephin (PSPN) is a neurotrophic factor of the glial cell line‐derived neurotrophic factor (GDNF) family that promotes survival of multiple populations of neurons. Little is known about the relevance of PSPN in human malignancy including oral squamous cell carcinoma (OSCC). This study was undertak...

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Bibliographic Details
Published in:Molecular carcinogenesis 2015-08, Vol.54 (8), p.608-617
Main Authors: Baba, Takao, Sakamoto, Yosuke, Kasamatsu, Atsushi, Minakawa, Yasuyuki, Yokota, Satoshi, Higo, Morihiro, Yokoe, Hidetaka, Ogawara, Katsunori, Shiiba, Masashi, Tanzawa, Hideki, Uzawa, Katsuhiro
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Cycle Checkpoints
Cell Line, Tumor
cell-cycle arrest
cyclin-dependent kinase inhibitors
Disease Progression
Humans
MAP Kinase Signaling System
Middle Aged
Mouth Neoplasms - genetics
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
oral squamous cell carcinoma
persephin
proliferation
Receptor Protein-Tyrosine Kinases - metabolism
Up-Regulation
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Summary:Persephin (PSPN) is a neurotrophic factor of the glial cell line‐derived neurotrophic factor (GDNF) family that promotes survival of multiple populations of neurons. Little is known about the relevance of PSPN in human malignancy including oral squamous cell carcinoma (OSCC). This study was undertaken to evaluate PSPN mRNA and protein expression by analyzing cellular proliferation and the cell cycle in PSPN knockdown cells in vitro. PSPN mRNA and protein were significantly (P 
ISSN:0899-1987
1098-2744
DOI:10.1002/mc.22127