High Ki-67 Expression Predicts Favorable Survival in Muscle-Invasive Bladder Cancer Patients Treated With Chemoradiation-Based Bladder-Sparing Protocol

Microabstract Reportedly, in bladder cancer patients, higher Ki-67 expression status is associated with poorer clinical outcomes after radical cystectomy. The current study demonstrated the application of induction chemoradiotherapy (CRT) may give survival benefits to muscle-invasive bladder cancer...

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Bibliographic Details
Published in:Clinical genitourinary cancer 2015-08, Vol.13 (4), p.e243-e251
Main Authors: Tanabe, Kenji, Yoshida, Soichiro, Koga, Fumitaka, Inoue, Masaharu, Kobayashi, Shuichiro, Ishioka, Junichiro, Tamura, Tomoki, Sugawara, Emiko, Saito, Kazutaka, Akashi, Takumi, Fujii, Yasuhisa, Kihara, Kazunori
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Chemoradiotherapy
Chemoradiotherapy - methods
Cisplatin - administration & dosage
Cisplatin - therapeutic use
Cystectomy - methods
Female
Hematology, Oncology and Palliative Medicine
Humans
Ki-67 antigen
Ki-67 Antigen - metabolism
Male
Middle Aged
Neoplasm Invasiveness
Organ preservation
Organ Sparing Treatments - methods
Prognosis
Survival Analysis
Treatment Outcome
Urinary bladder neoplasms
Urinary Bladder Neoplasms - metabolism
Urinary Bladder Neoplasms - surgery
Urinary Bladder Neoplasms - therapy
Urology
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Summary:Microabstract Reportedly, in bladder cancer patients, higher Ki-67 expression status is associated with poorer clinical outcomes after radical cystectomy. The current study demonstrated the application of induction chemoradiotherapy (CRT) may give survival benefits to muscle-invasive bladder cancer (MIBC) patients with high Ki-67 labeling index (LI). Favorable CRT response could potentially contribute to improved survival outcomes in MIBC patients with high Ki-67 LI.
ISSN:1558-7673
1938-0682
DOI:10.1016/j.clgc.2015.03.002