Rh(III)-Catalyzed C–H Amidation of Indoles with Isocyanates

The rhodium­(III)-catalyzed direct amidation of indoles and pyrroles with aryl and alkyl isocyanates is described. These transformations provide a facile and efficient construction of C2-amidated N-heterocyclic scaffolds.

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Bibliographic Details
Published in:Journal of organic chemistry 2015-07, Vol.80 (14), p.7243-7250
Main Authors: Jeong, Taejoo, Han, Sangil, Mishra, Neeraj Kumar, Sharma, Satyasheel, Lee, Seok-Yong, Oh, Joa Sub, Kwak, Jong Hwan, Jung, Young Hoon, Kim, In Su
Format: Article
Language:English
Subjects:
Amides - chemistry
Catalysis
Heterocyclic Compounds - chemical synthesis
Heterocyclic Compounds - chemistry
Indoles - chemistry
Isocyanates - chemistry
Molecular Structure
Pyrroles - chemistry
Rhodium - chemistry
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Description
Summary:The rhodium­(III)-catalyzed direct amidation of indoles and pyrroles with aryl and alkyl isocyanates is described. These transformations provide a facile and efficient construction of C2-amidated N-heterocyclic scaffolds.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.5b00763