Combined assessment of WT1 and BAALC gene expression at diagnosis may improve leukemia-free survival prediction in patients with myelodysplastic syndromes

Highlights • We analyzed WT1 and BAALC expression levels in MDS patients and diagnosis. • WT1 and BAALC combined assessment independently correlated with LFS duration. • Molecular evaluation could further improve IPSS and R-IPSS stratification. • Adding molecular data to standard prognostic score ma...

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Bibliographic Details
Published in:Leukemia research 2015-08, Vol.39 (8), p.866-873
Main Authors: Minetto, Paola, Guolo, Fabio, Clavio, Marino, De Astis, Enrico, Colombo, Nicoletta, Grasso, Raffaella, Fugazza, Giuseppina, Sessarego, Mario, Lemoli, Roberto Massimo, Gobbi, Marco, Miglino, Maurizio
Format: Article
Language:English
Subjects:
Adult
BAALC
Biomarkers, Tumor - genetics
Disease Progression
Disease-Free Survival
Female
Hematology, Oncology and Palliative Medicine
Humans
Leukemia, Myeloid, Acute - diagnosis
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - mortality
Leukemia, Myeloid, Acute - therapy
Leukemia-free survival
Male
MDS
Molecular analysis
Myelodysplastic Syndromes - diagnosis
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - pathology
Myelodysplastic Syndromes - therapy
Neoplasm Proteins - genetics
Prognosis
Retrospective Studies
Risk stratification
Survival Analysis
Transcriptome
WT1
WT1 Proteins - genetics
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Summary:Highlights • We analyzed WT1 and BAALC expression levels in MDS patients and diagnosis. • WT1 and BAALC combined assessment independently correlated with LFS duration. • Molecular evaluation could further improve IPSS and R-IPSS stratification. • Adding molecular data to standard prognostic score may help therapeutic choices.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2015.04.011