A case of primary pancreatic lymphoblastic lymphoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration

Pancreatic involvement is an extremely rare manifestation of lymphoblastic lymphoma (LBL), and only a few cases have been reported. We report a case of LBL arising from the pancreas that was diagnosed using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). The patient was a 57-year-old...

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Bibliographic Details
Published in:Clinical journal of gastroenterology 2014-04, Vol.7 (2), p.180-184
Main Authors: Nakaji, So, Hirata, Nobuto, Shiratori, Toshiyasu, Kobayashi, Masayoshi, Fujii, Hiroyuki, Ishii, Eiji, Matsue, Kosei, Hoshi, Kazuei
Format: Article
Language:English
Subjects:
Abdominal Surgery
Case Report
Colorectal Surgery
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Female
Gastroenterology
Hepatology
Humans
Medicine
Medicine & Public Health
Middle Aged
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Surgical Oncology
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Summary:Pancreatic involvement is an extremely rare manifestation of lymphoblastic lymphoma (LBL), and only a few cases have been reported. We report a case of LBL arising from the pancreas that was diagnosed using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). The patient was a 57-year-old female who had suffered from abdominal pain for 2 weeks. A physical examination revealed an upper abdominal mass, but did not detect peripheral lymphadenopathy. Imaging studies including computed tomography (CT) and 18 F-fluorodeoxy glucose (FDG)-positron emission tomography-CT revealed an enlarged pancreatic body, which was positive for FDG uptake. EUS-FNA detected medium-sized proliferating atypical lymphocytes, and immunohistochemical staining demonstrated that these cells were positive for CD20, CD10, PAX5, and terminal deoxynucleotidyl transferase. A bone marrow examination was negative for lymphoma infiltration, and a diagnosis of LBL arising from the pancreas was made. The patient was successfully treated with a combination of chemotherapy and pancreatic irradiation.
ISSN:1865-7257
1865-7265
DOI:10.1007/s12328-014-0462-x