Dickkopf-1 expression is down-regulated during the colorectal adenoma-carcinoma sequence and correlates with reduced microvessel density and VEGF expression

Aims Dickkopf‐1 (Dkk1), an antagonist of the Wnt–β‐catenin signalling pathway, has been reported to play a role in cancer progression. However, little is known about the role of Dkk1 during the colorectal adenoma–carcinoma sequence. This study aimed to elucidate the role of Dkk1 in tumorigenesis and...

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Bibliographic Details
Published in:Histopathology 2015-08, Vol.67 (2), p.158-166
Main Authors: Liu, Zhiyong, Sun, Baocun, Qi, Lisha, Li, Yixian, Zhao, Xiulan, Zhang, Danfang, Zhang, Yanhui
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
adenoma-carcinoma sequence
Adult
Aged
Aged, 80 and over
angiogenesis
Animals
Blotting, Western
colorectal cancer
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Dickkopf-1
Disease Progression
Down-Regulation
Female
Humans
Intercellular Signaling Peptides and Proteins - metabolism
Male
Mice
Microvessels - pathology
Middle Aged
Neovascularization, Physiologic - physiology
tumorigenesis
Vascular Endothelial Growth Factor A - metabolism
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Summary:Aims Dickkopf‐1 (Dkk1), an antagonist of the Wnt–β‐catenin signalling pathway, has been reported to play a role in cancer progression. However, little is known about the role of Dkk1 during the colorectal adenoma–carcinoma sequence. This study aimed to elucidate the role of Dkk1 in tumorigenesis and angiogenesis in colorectal cancer. Methods and results We examined Dkk1 expression immunohistochemically in 476 colorectal tissue samples, including 46 sets of matched specimens. Dkk1 expression was down‐regulated during the colorectal adenoma–carcinoma sequence, both among the 476 samples and in the 46 sets of matched specimens. Dkk1 expression was correlated with decreased microvessel density (P 
ISSN:0309-0167
1365-2559
DOI:10.1111/his.12474