Gastrointestinal dysfunction in Parkinson's disease

Summary Our understanding of dysfunction of the gastrointestinal system in patients with Parkinson's disease has increased substantially in the past decade. The entire gastrointestinal tract is affected in these patients, causing complications that range from oral issues, including drooling and...

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Bibliographic Details
Published in:Lancet neurology 2015-06, Vol.14 (6), p.625-639
Main Authors: Fasano, Alfonso, Dr, Visanji, Naomi P, PhD, Liu, Louis W C, MD, Lang, Antony E, Prof, Pfeiffer, Ronald F, Prof
Format: Article
Language:English
Subjects:
Comorbidity
Dopamine
Drug dosages
Gastrointestinal Diseases - complications
Gastrointestinal Diseases - drug therapy
Gastrointestinal Diseases - epidemiology
Humans
Hypotheses
Nervous system
Neurology
Ostomy
Parkinson Disease - drug therapy
Parkinson Disease - epidemiology
Parkinson Disease - etiology
Parkinson's disease
Physiology
Studies
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Summary:Summary Our understanding of dysfunction of the gastrointestinal system in patients with Parkinson's disease has increased substantially in the past decade. The entire gastrointestinal tract is affected in these patients, causing complications that range from oral issues, including drooling and swallowing problems, to delays in gastric emptying and constipation. Additionally, small intestinal bacterial overgrowth and Helicobacter pylori infection affect motor fluctuations by interfering with the absorption of antiparkinsonian drugs. The multifaceted role of the gastrointestinal system in Parkinson's disease necessitates a specific and detailed assessment and treatment plan. The presence of pervasive α-synuclein deposition in the gastrointestinal tract strongly implicates this system in the pathogenesis of Parkinson's disease. Future studies elucidating the role of the gastrointestinal tract in the pathological progression of Parkinson's disease might hold potential for early disease detection and development of neuroprotective approaches.
ISSN:1474-4422
1474-4465
DOI:10.1016/S1474-4422(15)00007-1