Verocytotoxin-1 induces apoptosis in vero cells

Epidemiological studies have firmly linked infection with verocytotoxin-producing Escherichia coli (VTEC) with both haemorrhagic colitis and childhood haemolytic uraemic syndrome (HUS). Eukaryotic cells in both physiological and pathological circumstances, may undergo gene-controlled programmed cell...

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Bibliographic Details
Published in:The Journal of infection 1995-05, Vol.30 (3), p.213-218
Main Authors: Inward, C.D., Williams, J., Chant, I., Crocker, J., Milford, D.V., Rose, P.E., Taylor, C.M.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Bacterial Toxins - toxicity
Biological and medical sciences
Cercopithecus aethiops
Cytotoxins - toxicity
Electrophoresis, Polyacrylamide Gel
Escherichia coli
General aspects
Humans
Infection pathogenesis
Infectious diseases
Medical sciences
Shiga Toxin 1
Vero Cells
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Summary:Epidemiological studies have firmly linked infection with verocytotoxin-producing Escherichia coli (VTEC) with both haemorrhagic colitis and childhood haemolytic uraemic syndrome (HUS). Eukaryotic cells in both physiological and pathological circumstances, may undergo gene-controlled programmed cell death; apoptosis. We have looked further into the mode of cell death using Vero cells, which are exquisitely sensitive to the toxin. The following experiments show that apoptosis is the principal mode of cell killing by VT1.
ISSN:0163-4453
1532-2742
DOI:10.1016/S0163-4453(95)90693-2