Aromatic DNA adducts in larynx biopsies and leukocytes

Larynx cancer is strongly associated with tobacco smoking. The objective of this work was an analysis of aromatic DNA adducts in tumour and non-tumour larynx cells by means of the 32P-postlabelling method. Peripheral blood leukocytes were used as a reference tissue. The presence of aromatic DNA addu...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1994-10, Vol.15 (10), p.2195-2199
Main Authors: Szyfter, K., Hemminki, K., Szyfter, W., Szmeja, Z., Banaszewski, J., Yang, K.
Format: Article
Language:English
Subjects:
Adult
Aged
Autoradiography
Biological and medical sciences
Biopsy
DNA Adducts - blood
DNA Adducts - metabolism
Female
Humans
Isotope Labeling
Laryngeal Neoplasms - blood
Laryngeal Neoplasms - metabolism
Laryngeal Neoplasms - pathology
Leukocytes - drug effects
Leukocytes - metabolism
Male
Medical sciences
Middle Aged
Phosphorus Radioisotopes
Pilot Projects
Pneumology
Polycyclic Compounds - metabolism
Polycyclic Compounds - toxicity
Smoking - adverse effects
Smoking - blood
Smoking - metabolism
Tumors of the respiratory system and mediastinum
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Summary:Larynx cancer is strongly associated with tobacco smoking. The objective of this work was an analysis of aromatic DNA adducts in tumour and non-tumour larynx cells by means of the 32P-postlabelling method. Peripheral blood leukocytes were used as a reference tissue. The presence of aromatic DNA adducts was demonstrated in all the studied tissues obtained after surgery of larynx tumours. The highest level of DNA adducts was found in larynx tumour cells, followed by non-tumour larynx cells, which exceeded that found in leukocytes almost 2.5 times. Large interindividual differences were detected between subjects. The adduct level in tumour/non-tumour correlated only moderately. However a high correlation was found between the level of DNA adducts in larynx (tumour and nontumour) cells and that in leukocytes.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/15.10.2195