Peri-Incisional Botulinum Toxin for Chronic Postcraniotomy Headache After Traumatic Brain Injury: A Case Series

Abstract Botulinum neurotoxin (BoNT) has been used successfully to treat primary headache syndromes, but there are no published data on its use for chronic postcraniotomy headache. Botulinum neurotoxin type A (BoNT-A) (4:1 dilution) was injected at a dose of 15-50 units into peri-incisional sites of...

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Bibliographic Details
Published in:PM & R 2015-07, Vol.7 (7), p.785-788
Main Authors: MacKenzie, Heather M., MD, Teasell, Robert, MD, FRCPC, Miller, Thomas A., MD, FRCPC, Sequeira, Keith, MD, FRCPC
Format: Article
Language:English
Subjects:
Adult
Botulinum Toxins, Type A - administration & dosage
Brain Injuries - surgery
Craniotomy - adverse effects
Female
Follow-Up Studies
Headache Disorders - drug therapy
Headache Disorders - etiology
Humans
Injections
Male
Middle Aged
Neuromuscular Agents - administration & dosage
Pain, Postoperative - drug therapy
Pain, Postoperative - etiology
Physical Medicine and Rehabilitation
Preoperative Care - methods
Young Adult
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Summary:Abstract Botulinum neurotoxin (BoNT) has been used successfully to treat primary headache syndromes, but there are no published data on its use for chronic postcraniotomy headache. Botulinum neurotoxin type A (BoNT-A) (4:1 dilution) was injected at a dose of 15-50 units into peri-incisional sites of the scalp in 3 patients who had undergone craniotomy remotely for traumatic epidural hematoma. All patients reported reductions in headache lasting at least 2.5 months. Repeat injections were performed in all cases with favorable outcomes. There were no complications. Peri-incisional BoNT-A appears to be a potentially valuable tool in the chronic management of post craniotomy headache after traumatic brain injury.
ISSN:1934-1482
1934-1563
DOI:10.1016/j.pmrj.2015.02.015