Changes in gastric sodium–iodide symporter (NIS) activity are associated with differences in thyroid gland sensitivity to perchlorate during metamorphosis

Highlights • Stage 55 tadpoles are less sensitive than earlier stage tadpoles to perchlorate. • Perchlorate blocks I− uptake in many non-thyroid tissues in tadpoles. • Perchlorate sensitive I− uptake was greatest in stomach. • Perchlorate-sensitive I− uptake in stomach was greater at stage 55 than s...

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Bibliographic Details
Published in:General and comparative endocrinology 2015-08, Vol.219, p.16-23
Main Authors: Carr, James A, Murali, Sharanya, Hu, Fang, Goleman, Wanda L, Carr, Deborah L, Smith, Ernest E, Wages, Mike
Format: Article
Language:English
Subjects:
Amphibian
Animals
Development
Endocrinology & Metabolism
Female
Iodide
Larva - metabolism
Male
Metamorphosis
Metamorphosis, Biological - genetics
Perchlorates - metabolism
Symporters - genetics
Thyroid
Thyroid Gland - metabolism
Xenopus laevis - metabolism
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Summary:Highlights • Stage 55 tadpoles are less sensitive than earlier stage tadpoles to perchlorate. • Perchlorate blocks I− uptake in many non-thyroid tissues in tadpoles. • Perchlorate sensitive I− uptake was greatest in stomach. • Perchlorate-sensitive I− uptake in stomach was greater at stage 55 than stage 49.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2014.10.018