Three randomized trials of maternal influenza immunization in Mali, Nepal, and South Africa: Methods and expectations

Highlights • Maternal immunization is an appealing strategy to protect pregnant women and their infants. • The Bill & Melinda Gates Foundation is supporting randomized trials in Nepal, Mali, and South Africa. • We present a side-by-side description of the three studies including similarities and...

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Bibliographic Details
Published in:Vaccine 2015-07, Vol.33 (32), p.3801-3812
Main Authors: Omer, Saad B, Richards, Jennifer L, Madhi, Shabir A, Tapia, Milagritos D, Steinhoff, Mark C, Aqil, Anushka R, Wairagkar, Niteen
Format: Article
Language:English
Subjects:
Age
Allergy and Immunology
Babies
Clinical trials
Epidemiology
Female
Humans
Illnesses
Immunization
Immunization - methods
Infants
Infections
Influenza
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza, Human - prevention & control
Laboratories
Mali
Maternal immunization
Meta-analysis
Mortality
Nepal
Pooled analyses
Pregnancy
Pregnancy Complications, Infectious - prevention & control
Randomized Controlled Trials as Topic
Seasons
South Africa
Studies
Vaccines
Viral infections
Womens health
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Summary:Highlights • Maternal immunization is an appealing strategy to protect pregnant women and their infants. • The Bill & Melinda Gates Foundation is supporting randomized trials in Nepal, Mali, and South Africa. • We present a side-by-side description of the three studies including similarities and differences. • Further research is needed on logistics for vaccine supply, surveillance, and optimal delivery strategies.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.05.077