Relationship between intravoxel incoherent motion diffusion-weighted MRI and dynamic contrast-enhanced MRI in tissue perfusion of cervical cancers

• Published in: Journal of magnetic resonance imaging 2015-08, Vol.42 (2), p.454-459
• Main Authors: Lee, Elaine Yuen Phin, Hui, Edward Sai Kam, Chan, Karen Kar Loen, Tse, Ka Yu, Kwong, Wai Kay, Chang, Tien Yee, Chan, Queenie, Khong, Pek-Lan
• Format: Article
• Language: English
• Subjects: Adult; Aged; Algorithms; cervical cancer; Contrast Media; DCE-MRI; Diffusion Magnetic Resonance Imaging - methods; Female; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Imaging, Three-Dimensional - methods; intravoxel incoherent motion; IVIM; Magnetic resonance imaging; Meglumine; Middle Aged; Motion; Organometallic Compounds; perfusion; Perfusion Imaging - methods; Reproducibility of Results; Sensitivity and Specificity; Uterine Cervical Neoplasms - pathology
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.24808

Purpose To investigate the relationship between intravoxel incoherent motion (IVIM) diffusion‐weighted magnetic resonance imaging (MRI) and dynamic contrast‐enhanced MRI (DCE‐MRI) in cervical cancer perfusion. Materials and Methods Prospective newly diagnosed cervical cancer patients underwent diffusion‐weighted MRI (13 b‐values: 1–1000 s/mm2) and DCE‐MRI. The IVIM perfusion parameters, perfusion fraction (f), pseudodiffusion coefficient (D*), and flow‐related parameter (fD*), were derived from a biexponential decay model. DCE‐MRI was analyzed with a pharmacokinetic model and signal‐time curve to derive the amplitude factor (A), estimated volume transfer constant between blood plasma, and the extravascular extracellular space (estKtrans), maximum relative enhancement (MaxRE), and area under the signal‐time curve (AUC). Spearman's rank correlation coefficient (r) evaluated the correlative relationships. Results The f = 13.51% ± 1.76%, D* = 71.72 ± 7.55 × 10−3 mm2/s, fD* = 9.64 ± 1.28 × 10−3 mm2/s, A = 1.41 ± 0.43, estKtrans = 0.19 ± 0.06 s−1, MaxRE of 120.02 ± 21.07%, and AUC 212,393 ± 54,423 was found in 25 cervical cancer patients. Statistically significant positive correlations were found between fD* and estKtrans (r = 0.42, P = 0.038), fD* and A (r = 0.50, P = 0.011), fD* and MaxRE (r = 0.52, P = 0.008), f and AUC (r = 0.58, P = 0.003). Conclusion: The IVIM perfusion parameters showed moderate to good correlations with quantitative and semiquantitative perfusion parameters derived from DCE‐MRI in cervical cancer. J. Magn. Reson. Imaging 2014. J. Magn. Reson. Imaging 2015;42:454–459.