Daptomycin combinations as alternative therapies in experimental foreign-body infection caused by meticillin-susceptible Staphylococcus aureus

Highlights • Daptomycin combinations in foreign-body infection caused by meticillin-susceptible Staphylococcus aureus were studied. • Daptomycin+rifampicin (DAP+RIF) was the most effective treatment. • DAP+RIF was more effective than standard levofloxacin+rifampicin (LVX+RIF). • There were no differ...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2015-08, Vol.46 (2), p.189-195
Main Authors: El Haj, Cristina, Murillo, Oscar, Ribera, Alba, Vivas, Mireia, Garcia-Somoza, Dolors, Tubau, Fe, Cabellos, Carmen, Cabo, Javier, Ariza, Javier
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - administration & dosage
Colony Count, Microbial
Combination therapy
Complementary Therapies - methods
Daptomycin
Daptomycin - administration & dosage
Disease Models, Animal
Drug Therapy, Combination - methods
Foreign Bodies - complications
Foreign-body infection
Infectious Disease
Levofloxacin - administration & dosage
Male
MSSA
Rats, Wistar
Rifampin - administration & dosage
Staphylococcal Infections - drug therapy
Staphylococcus aureus - drug effects
Treatment Outcome
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Summary:Highlights • Daptomycin combinations in foreign-body infection caused by meticillin-susceptible Staphylococcus aureus were studied. • Daptomycin+rifampicin (DAP+RIF) was the most effective treatment. • DAP+RIF was more effective than standard levofloxacin+rifampicin (LVX+RIF). • There were no differences between LVX+DAP and LVX+RIF combinations. • Combined therapies prevented the emergence of resistance.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2015.04.004