Structure and biosynthesis of toxins from blue-green algae (cyanobacteria)

Microcystis and Nodularia species produce cyclic hepta- and pentapeptides, microcystins and nodularin, respectively, both containing the same unusual C sub(20) amino acid, abbreviated Adda. Biosynthesis of nodularin from Nodularia and especially of Adda employs a pathway similar to that employed by...

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Bibliographic Details
Published in:Journal of applied phycology 1994-04, Vol.6 (2), p.159-176
Main Authors: Rinehart, Kenneth L., Namikoshi, Michio, Choi, Byoung W.
Format: Article
Language:English
Subjects:
Cyanophyta
Freshwater
Microcystis
Nodularia
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Summary:Microcystis and Nodularia species produce cyclic hepta- and pentapeptides, microcystins and nodularin, respectively, both containing the same unusual C sub(20) amino acid, abbreviated Adda. Biosynthesis of nodularin from Nodularia and especially of Adda employs a pathway similar to that employed by Microcystis for producing microcystins. Nearly 30 new microcystins have been isolated in our laboratory from cyanobacteria species and their structures assigned, largely employing tandem FAB mass spectrometry (FABMS/CID/MS). Acyclic peptides, some of them presumed precursors of nodularin and microcystins, have now been isolated and characterized. The numerous analogs identified or synthesized allow the identification of important parameters in a structure-activity relationship study.
ISSN:0921-8971
1573-5176
DOI:10.1007/BF02186070