Anti-inflammatory Strategies to Prevent Diabetic Cardiovascular Disease

Diabetes is a proinflammatory state and inflammation is crucial in the genesis of vascular complications. While there are many anti‐inflammatory strategies, most of which have been shown to reduce inflammation in diabetes, there is sparse data on reduction in cardiovascular events (CVEs). To date, t...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2015-08, Vol.98 (2), p.121-123
Main Authors: Jialal, I, Devaraj, S
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - therapeutic use
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - immunology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - prevention & control
Diabetes Mellitus - diagnosis
Diabetes Mellitus - drug therapy
Diabetes Mellitus - immunology
Diabetes Mellitus - metabolism
Diabetic Angiopathies - diagnosis
Diabetic Angiopathies - immunology
Diabetic Angiopathies - metabolism
Diabetic Angiopathies - prevention & control
Humans
Inflammation Mediators - antagonists & inhibitors
Inflammation Mediators - metabolism
Risk Assessment
Risk Factors
Signal Transduction - drug effects
Treatment Outcome
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Summary:Diabetes is a proinflammatory state and inflammation is crucial in the genesis of vascular complications. While there are many anti‐inflammatory strategies, most of which have been shown to reduce inflammation in diabetes, there is sparse data on reduction in cardiovascular events (CVEs). To date, the only anti‐inflammatory strategies that have been shown to reduce CVE in diabetes include statins, angiotensin receptor blockers, metformin, and pioglitazone. We also discuss the role of novel emerging therapies.
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt.105