The role of fibroblast growth factor 21 in diabetes and its complications: A review from clinical perspective

Highlights • Circulating FGF21 level is increased in patients with type 2 diabetes (T2DM). • Increased level of FGF21 in patients with T2DM may be attributable to FGF21 resistance. • Circulating FGF21 level is associated with both micro- and macro-vascular complications in patients with T2DM. • FGF2...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2015-06, Vol.108 (3), p.382-389
Main Authors: Liu, Jian-Jun, Foo, Joo Pin, Liu, Sylvia, Lim, Su Chi
Format: Article
Language:English
Subjects:
Diabetes
Diabetes complications
Diabetes Complications - blood
Diabetes Mellitus, Type 2 - blood
Diabetes therapy
Endocrinology & Metabolism
Fibroblast growth factor 21
Fibroblast Growth Factors - blood
Humans
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Summary:Highlights • Circulating FGF21 level is increased in patients with type 2 diabetes (T2DM). • Increased level of FGF21 in patients with T2DM may be attributable to FGF21 resistance. • Circulating FGF21 level is associated with both micro- and macro-vascular complications in patients with T2DM. • FGF21 may be a mediator of anti-diabetic drugs. • FGF21 signaling pathway is a potential therapeutic target for treatment of T2DM and its complications.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2015.02.032