III. Nitric oxide. Role of induced nitric oxide synthase and increased NO levels in zymosan peritonitis in the rat

Inflammatory cytokines and LPS induce a calcium-independent NO synthase (i-NOS) in a variety of cell types including: macrophages, neutrophils and vascular smooth muscle and endothelial cells. NO production by macrophages is cytotoxic to some organisms and has been implicated in non-specific host de...

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Published in:Inflammation research 1995-01
Format: Article
Language:English
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Summary:Inflammatory cytokines and LPS induce a calcium-independent NO synthase (i-NOS) in a variety of cell types including: macrophages, neutrophils and vascular smooth muscle and endothelial cells. NO production by macrophages is cytotoxic to some organisms and has been implicated in non-specific host defence, at least in rodents. In addition, the excessive production of NO and oxidative products are cytotoxic to host cells, including the vascular endothelium. Furthermore, excessive nitric oxide production following NOS induction in-vivo has been implicated in the vascular leakage produced in the rat intestine after LPS and in carrageenin paw oedema. We have investigated the role of i-NOS in zymosan peritonitis in the rat and determined the consequences of enhanced NO production following NOS induction by LPS in this model of inflammation.
ISSN:1023-3830