Total skin clearance results in improvements in health-related quality of life and reduced symptom severity among patients with moderate to severe psoriasis

Background: Newer therapies provide high levels of skin clearance in patients with moderate to severe psoriasis. However, insufficient evidence exists on the impact of total skin clearance from the patient's perspective. Objectives: To examine effects of total skin clearance on health-related q...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2015-06, Vol.26 (3), p.235-239
Main Authors: Viswanathan, Hema N., Chau, Dina, Milmont, Cassandra E., Yang, Wenjjing, Erondu, Ngozi, Revicki, Dennis A., Klekotka, Paul
Format: Article
Language:English
Subjects:
Adult
Antibodies, Monoclonal - therapeutic use
Brodalumab
dermatology life quality index
Double-Blind Method
Female
health-related quality of life
Humans
Male
Middle Aged
patient-reported outcomes
plaque psoriasis
Pruritus - etiology
Psoriasis - pathology
psoriasis area and severity index
psoriasis symptom inventory
Quality of Life
Severity of Illness Index
Skin - pathology
static physician global assessment
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Summary:Background: Newer therapies provide high levels of skin clearance in patients with moderate to severe psoriasis. However, insufficient evidence exists on the impact of total skin clearance from the patient's perspective. Objectives: To examine effects of total skin clearance on health-related quality of life (HRQoL) and psoriasis symptom severity in subjects with moderate to severe psoriasis. Methods: Pooled data from a phase 2 dose-ranging trial in psoriasis using brodalumab (antibody to interleukin-17 receptor A) were used to compare subjects with static physician global assessment (sPGA) 1 versus sPGA 0 and subjects with Psoriasis Area and Severity Index (PASI) 75 to
ISSN:0954-6634
1471-1753
DOI:10.3109/09546634.2014.943687