Serum Gamma-glutamyltransferase Levels Predict the Progression of Coronary Artery Calcification in Adults With Type 2 Diabetes Mellitus

Progression of coronary artery calcification (CAC) may be more predictive of future coronary heart disease events than a baseline CAC score. We determined whether serum gamma-glutamyltransferase (GGT) activity can independently predict the progression of CAC in adults with type 2 diabetes mellitus (...

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Bibliographic Details
Published in:Angiology 2015-08, Vol.66 (7), p.667-674
Main Authors: Gang, Li, Wei-Hua, Lu, Rong, Ai, Jian-Hong, Yang, Zi-Hua, Zhou, Zhong-Zhi, Tang
Format: Article
Language:English
Subjects:
Biomarkers - blood
Calcinosis - blood
Calcinosis - physiopathology
Coronary Artery Disease - blood
Coronary Artery Disease - physiopathology
Diabetes Mellitus, Type 2 - complications
Disease Progression
Female
gamma-Glutamyltransferase - blood
Humans
Male
Middle Aged
Predictive Value of Tests
Risk Factors
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Summary:Progression of coronary artery calcification (CAC) may be more predictive of future coronary heart disease events than a baseline CAC score. We determined whether serum gamma-glutamyltransferase (GGT) activity can independently predict the progression of CAC in adults with type 2 diabetes mellitus (T2DM). Patients (n = 326) without symptomatic cardiovascular (CV) disease were evaluated by CAC imaging. The CAC scores were assessed at baseline and after 20 ± 4 months. Serum GGT activities were significantly higher in progressors compared with nonprogressors (39 ± 16 vs 27 ± 11 U/L, P < .001). Multivariable analyses demonstrated that GGT activity retained a strong association with CAC progression after adjustment for CV risk factors. Additionally, there was a graded association between GGT activity quartile and annualized CAC progression. In asymptomatic patients with T2DM, we prospectively found that serum GGT activity may be an independent predictor of CAC progression but not a predictor of CAC incidence.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319714548566