Increased Platelet Distribution Width Is Associated With Severity of Coronary Artery Disease in Patients With Acute Coronary Syndrome

• Published in: Angiology 2015-08, Vol.66 (7), p.638-643
• Main Authors: Bekler, Adem, Ozkan, Muhammed Turgut Alper, Tenekecioglu, Erhan, Gazi, Emine, Yener, Ali Umit, Temiz, Ahmet, Altun, Burak, Barutcu, Ahmet, Erbag, Gokhan, Binnetoglu, Emine
• Format: Article
• Language: English
• Subjects: Acute Coronary Syndrome - blood; Acute Coronary Syndrome - diagnostic imaging; Adult; Aged; Aged, 80 and over; Blood Cell Count; Blood Platelets - pathology; Coronary Angiography; Echocardiography; Female; Humans; Male; Middle Aged; Platelet Activation; Retrospective Studies; Risk Factors; Severity of Illness Index
• ISSN: 0003-3197; 1940-1574
• DOI: 10.1177/0003319714545779

Platelet activation plays a pivotal role in acute coronary syndrome (ACS). We investigated the relationship between platelet distribution width (PDW) and severity of coronary artery disease (CAD) in patients with ACS. A total of 502 patients with ACS were enrolled. High (n = 151) and low PDW (n = 351) groups were defined as patients having values in the third tertile (>17%) and lower 2 tertiles (≤17%). There were significantly higher Gensini score (44 [10-168] vs 36 [2-132], P < .001), and neutrophil–lymphocyte ratio (3.1 [0.8-12.4] vs 2.5 [0.3-13], P = .012) and baseline platelet counts were significantly lower (220 [61-623] vs 233 [79-644] 103/mm3, P = .022) in the high PDW group. The variables PDW >17%, diabetes mellitus, and myocardial infarction were found to be associated with high Gensini score (odds ratio [OR]: 1.91, 95% confidence interval [CI]: 1.27-2.88, P = .002; OR: 2.85, 95%CI: 1.91-4.25, P < .001; OR: 2.67, 95% CI:1.74-4.1, P < .001, respectively). An increased PDW (>17%) is associated with severity of CAD in patients with ACS.