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Estimation of the prevalence of asymptomatic pancreatic cysts in the population of San Marino
Abstract Background There has been a dramatic increase in the number of pancreatic cystic lesions observed in the past two decades but data regarding the prevalence of cysts in the general population are lacking. Methods All the individuals who undergo CT at the San Marino State Hospital are residen...
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| Published in: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2015-07, Vol.15 (4), p.417-422 |
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| container_title | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] |
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| creator | Zanini, Nicola Giordano, Marco Smerieri, Elia Cipolla d'Abruzzo, Giulio Guidi, Marilyn Pazzaglini, Giorgio De Luca, Fiorella Chiaruzzi, Giorgia Vitullo, Giovanni Piva, Paolo Lombardi, Raffaele Jovine, Elio Gatti, Marino Landolfo, Giovanni |
| description | Abstract Background There has been a dramatic increase in the number of pancreatic cystic lesions observed in the past two decades but data regarding the prevalence of cysts in the general population are lacking. Methods All the individuals who undergo CT at the San Marino State Hospital are residents of the Republic of San Marino; their demographic distribution is available and precise. CT scans carried out over 1 year at the State Hospital were reviewed for asymptomatic pancreatic cysts. Results 1061 relevant CT scans were carried out on 814 patients; 762 individuals were eligible for the study and 650 patients underwent contrast-enhanced CT. Thirty-five patients had at least one cyst at contrast-enhanced CT (5.4%). The prevalence of cysts increased with increasing age up to 13.4% (95% CI 6.6–20) in individuals 80–89 years of age (p |
| doi_str_mv | 10.1016/j.pan.2015.05.461 |
| format | article |
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Methods All the individuals who undergo CT at the San Marino State Hospital are residents of the Republic of San Marino; their demographic distribution is available and precise. CT scans carried out over 1 year at the State Hospital were reviewed for asymptomatic pancreatic cysts. Results 1061 relevant CT scans were carried out on 814 patients; 762 individuals were eligible for the study and 650 patients underwent contrast-enhanced CT. Thirty-five patients had at least one cyst at contrast-enhanced CT (5.4%). The prevalence of cysts increased with increasing age up to 13.4% (95% CI 6.6–20) in individuals 80–89 years of age (p < .001). Cyst prevalence was significantly higher in patients who underwent CT for malignancy (p = .038) but this difference was no longer significant in multivariate analysis. The odds of a cyst being present increased by 1.05 (95% CI 1.02–1.09) for each increasing year of age (p = .002). Approximately a quarter of the patients with cysts died within 1 year after CT from non pancreas-related disease. The estimated standardized age-adjusted cyst prevalence is 2194 per 100,000 people. Conclusions The likelihood of having a pancreatic cyst correlates with increasing age, not with the presence of extra-pancreatic malignancies. The estimated prevalence of CT-detectable asymptomatic pancreatic cysts in the general population is 2.2%.</description><identifier>ISSN: 1424-3903</identifier><identifier>EISSN: 1424-3911</identifier><identifier>DOI: 10.1016/j.pan.2015.05.461</identifier><identifier>PMID: 26028332</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Computed tomography ; Contrast Media ; Cyst ; Cysts ; Endocrinology & Metabolism ; Epidemiology ; Family medical history ; Female ; Gastroenterology and Hepatology ; Humans ; Image Processing, Computer-Assisted ; IPMN ; Male ; Medical imaging ; Middle Aged ; Multivariate analysis ; Neoplasms - complications ; Neoplasms - epidemiology ; NMR ; Nuclear magnetic resonance ; Pancreas ; Pancreatic cancer ; Pancreatic Cyst - diagnosis ; Pancreatic Cyst - epidemiology ; Pancreatic Cyst - mortality ; Patients ; Population ; Prevalence ; San Marino - epidemiology ; Sex Factors ; Surgery ; Tomography, X-Ray Computed ; Ultrasonic imaging ; Young Adult</subject><ispartof>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2015-07, Vol.15 (4), p.417-422</ispartof><rights>IAP and EPC</rights><rights>2015 IAP and EPC</rights><rights>Copyright © 2015 IAP and EPC. Published by Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Limited Jul/Aug 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-f7880904023cbcb531aafdd43ea9cc870ac6a2bcb9ae6116a96a2cbd186909af3</citedby><cites>FETCH-LOGICAL-c535t-f7880904023cbcb531aafdd43ea9cc870ac6a2bcb9ae6116a96a2cbd186909af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26028332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zanini, Nicola</creatorcontrib><creatorcontrib>Giordano, Marco</creatorcontrib><creatorcontrib>Smerieri, Elia</creatorcontrib><creatorcontrib>Cipolla d'Abruzzo, Giulio</creatorcontrib><creatorcontrib>Guidi, Marilyn</creatorcontrib><creatorcontrib>Pazzaglini, Giorgio</creatorcontrib><creatorcontrib>De Luca, Fiorella</creatorcontrib><creatorcontrib>Chiaruzzi, Giorgia</creatorcontrib><creatorcontrib>Vitullo, Giovanni</creatorcontrib><creatorcontrib>Piva, Paolo</creatorcontrib><creatorcontrib>Lombardi, Raffaele</creatorcontrib><creatorcontrib>Jovine, Elio</creatorcontrib><creatorcontrib>Gatti, Marino</creatorcontrib><creatorcontrib>Landolfo, Giovanni</creatorcontrib><title>Estimation of the prevalence of asymptomatic pancreatic cysts in the population of San Marino</title><title>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</title><addtitle>Pancreatology</addtitle><description>Abstract Background There has been a dramatic increase in the number of pancreatic cystic lesions observed in the past two decades but data regarding the prevalence of cysts in the general population are lacking. Methods All the individuals who undergo CT at the San Marino State Hospital are residents of the Republic of San Marino; their demographic distribution is available and precise. CT scans carried out over 1 year at the State Hospital were reviewed for asymptomatic pancreatic cysts. Results 1061 relevant CT scans were carried out on 814 patients; 762 individuals were eligible for the study and 650 patients underwent contrast-enhanced CT. Thirty-five patients had at least one cyst at contrast-enhanced CT (5.4%). The prevalence of cysts increased with increasing age up to 13.4% (95% CI 6.6–20) in individuals 80–89 years of age (p < .001). Cyst prevalence was significantly higher in patients who underwent CT for malignancy (p = .038) but this difference was no longer significant in multivariate analysis. The odds of a cyst being present increased by 1.05 (95% CI 1.02–1.09) for each increasing year of age (p = .002). Approximately a quarter of the patients with cysts died within 1 year after CT from non pancreas-related disease. The estimated standardized age-adjusted cyst prevalence is 2194 per 100,000 people. Conclusions The likelihood of having a pancreatic cyst correlates with increasing age, not with the presence of extra-pancreatic malignancies. The estimated prevalence of CT-detectable asymptomatic pancreatic cysts in the general population is 2.2%.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Computed tomography</subject><subject>Contrast Media</subject><subject>Cyst</subject><subject>Cysts</subject><subject>Endocrinology & Metabolism</subject><subject>Epidemiology</subject><subject>Family medical history</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>IPMN</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - epidemiology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Cyst - diagnosis</subject><subject>Pancreatic Cyst - epidemiology</subject><subject>Pancreatic Cyst - mortality</subject><subject>Patients</subject><subject>Population</subject><subject>Prevalence</subject><subject>San Marino - epidemiology</subject><subject>Sex Factors</subject><subject>Surgery</subject><subject>Tomography, X-Ray Computed</subject><subject>Ultrasonic imaging</subject><subject>Young Adult</subject><issn>1424-3903</issn><issn>1424-3911</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kUFv1DAQhS0EoqXwA7igSFy4bJixEycWElJVlRapiEOp1EtleZ2J8JK1g51U2n-P0y2L1AMnj-333tjfMPYWoURA-XFTjsaXHLAuoS4ric_YMVa8WgmF-PxQgzhir1LaAHCOqF6yIy6Bt0LwY3Z3nia3NZMLvgh9Mf2kYox0bwbylpYTk3bbcQqLxBa5nY30UNpdmlLh_N4Sxnk4hFwbX3wz0fnwmr3ozZDozeN6wm6-nP84u1xdfb_4enZ6tbK1qKdV37QtKKiAC7u261qgMX3XVYKMsrZtwFhpeL5RhiSiNCpv7brDVipQphcn7MM-d4zh90xp0luXLA2D8RTmpFGqVklZqSZL3z-RbsIcfX6dxgbajAwbnlW4V9kYUorU6zFmTHGnEfTCXm90hqEX9hpqndlnz7vH5Hm9pe7g-As7Cz7tBZRR3DuKOlm3cO5cJDvpLrj_xn9-4raD886a4RftKP37hU5cg75ehr_MHmuAum5vxR9_c6nN</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Zanini, Nicola</creator><creator>Giordano, Marco</creator><creator>Smerieri, Elia</creator><creator>Cipolla d'Abruzzo, Giulio</creator><creator>Guidi, Marilyn</creator><creator>Pazzaglini, Giorgio</creator><creator>De Luca, Fiorella</creator><creator>Chiaruzzi, Giorgia</creator><creator>Vitullo, Giovanni</creator><creator>Piva, Paolo</creator><creator>Lombardi, Raffaele</creator><creator>Jovine, Elio</creator><creator>Gatti, Marino</creator><creator>Landolfo, Giovanni</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20150701</creationdate><title>Estimation of the prevalence of asymptomatic pancreatic cysts in the population of San Marino</title><author>Zanini, Nicola ; Giordano, Marco ; Smerieri, Elia ; Cipolla d'Abruzzo, Giulio ; Guidi, Marilyn ; Pazzaglini, Giorgio ; De Luca, Fiorella ; Chiaruzzi, Giorgia ; Vitullo, Giovanni ; Piva, Paolo ; Lombardi, Raffaele ; Jovine, Elio ; Gatti, Marino ; Landolfo, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-f7880904023cbcb531aafdd43ea9cc870ac6a2bcb9ae6116a96a2cbd186909af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Computed tomography</topic><topic>Contrast Media</topic><topic>Cyst</topic><topic>Cysts</topic><topic>Endocrinology & Metabolism</topic><topic>Epidemiology</topic><topic>Family medical history</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>IPMN</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - epidemiology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pancreas</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Cyst - diagnosis</topic><topic>Pancreatic Cyst - epidemiology</topic><topic>Pancreatic Cyst - mortality</topic><topic>Patients</topic><topic>Population</topic><topic>Prevalence</topic><topic>San Marino - epidemiology</topic><topic>Sex Factors</topic><topic>Surgery</topic><topic>Tomography, X-Ray Computed</topic><topic>Ultrasonic imaging</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zanini, Nicola</creatorcontrib><creatorcontrib>Giordano, Marco</creatorcontrib><creatorcontrib>Smerieri, Elia</creatorcontrib><creatorcontrib>Cipolla d'Abruzzo, Giulio</creatorcontrib><creatorcontrib>Guidi, Marilyn</creatorcontrib><creatorcontrib>Pazzaglini, Giorgio</creatorcontrib><creatorcontrib>De Luca, Fiorella</creatorcontrib><creatorcontrib>Chiaruzzi, Giorgia</creatorcontrib><creatorcontrib>Vitullo, Giovanni</creatorcontrib><creatorcontrib>Piva, Paolo</creatorcontrib><creatorcontrib>Lombardi, Raffaele</creatorcontrib><creatorcontrib>Jovine, Elio</creatorcontrib><creatorcontrib>Gatti, Marino</creatorcontrib><creatorcontrib>Landolfo, Giovanni</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zanini, Nicola</au><au>Giordano, Marco</au><au>Smerieri, Elia</au><au>Cipolla d'Abruzzo, Giulio</au><au>Guidi, Marilyn</au><au>Pazzaglini, Giorgio</au><au>De Luca, Fiorella</au><au>Chiaruzzi, Giorgia</au><au>Vitullo, Giovanni</au><au>Piva, Paolo</au><au>Lombardi, Raffaele</au><au>Jovine, Elio</au><au>Gatti, Marino</au><au>Landolfo, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimation of the prevalence of asymptomatic pancreatic cysts in the population of San Marino</atitle><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle><addtitle>Pancreatology</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>15</volume><issue>4</issue><spage>417</spage><epage>422</epage><pages>417-422</pages><issn>1424-3903</issn><eissn>1424-3911</eissn><abstract>Abstract Background There has been a dramatic increase in the number of pancreatic cystic lesions observed in the past two decades but data regarding the prevalence of cysts in the general population are lacking. Methods All the individuals who undergo CT at the San Marino State Hospital are residents of the Republic of San Marino; their demographic distribution is available and precise. CT scans carried out over 1 year at the State Hospital were reviewed for asymptomatic pancreatic cysts. Results 1061 relevant CT scans were carried out on 814 patients; 762 individuals were eligible for the study and 650 patients underwent contrast-enhanced CT. Thirty-five patients had at least one cyst at contrast-enhanced CT (5.4%). The prevalence of cysts increased with increasing age up to 13.4% (95% CI 6.6–20) in individuals 80–89 years of age (p < .001). Cyst prevalence was significantly higher in patients who underwent CT for malignancy (p = .038) but this difference was no longer significant in multivariate analysis. The odds of a cyst being present increased by 1.05 (95% CI 1.02–1.09) for each increasing year of age (p = .002). Approximately a quarter of the patients with cysts died within 1 year after CT from non pancreas-related disease. The estimated standardized age-adjusted cyst prevalence is 2194 per 100,000 people. Conclusions The likelihood of having a pancreatic cyst correlates with increasing age, not with the presence of extra-pancreatic malignancies. The estimated prevalence of CT-detectable asymptomatic pancreatic cysts in the general population is 2.2%.</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>26028332</pmid><doi>10.1016/j.pan.2015.05.461</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Age Age Factors Aged Aged, 80 and over Computed tomography Contrast Media Cyst Cysts Endocrinology & Metabolism Epidemiology Family medical history Female Gastroenterology and Hepatology Humans Image Processing, Computer-Assisted IPMN Male Medical imaging Middle Aged Multivariate analysis Neoplasms - complications Neoplasms - epidemiology NMR Nuclear magnetic resonance Pancreas Pancreatic cancer Pancreatic Cyst - diagnosis Pancreatic Cyst - epidemiology Pancreatic Cyst - mortality Patients Population Prevalence San Marino - epidemiology Sex Factors Surgery Tomography, X-Ray Computed Ultrasonic imaging Young Adult |
| title | Estimation of the prevalence of asymptomatic pancreatic cysts in the population of San Marino |
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