Malignant fibrous histiocytoma of the penis

According to the most recent World Health Organization (WHO) guidelines a diagnosis of malignant fibrous histiocytoma (MFH) should be made only for lesions composed of tumor cells without evidence of a specific line of differentiation. This is therefore a diagnosis by exclusion which is why the name...

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Bibliographic Details
Published in:Der Pathologe 2015-07, Vol.36 (4), p.385-388
Main Authors: Crisman, G, Margiotta, G, Calabresi, M, Discepoli, S, Leocata, P
Format: Article
Language:ger
Subjects:
Biopsy
Diagnosis, Differential
Guideline Adherence
Histiocytoma, Malignant Fibrous - pathology
Humans
Male
Middle Aged
Neoplasm Grading
Penile Neoplasms - pathology
Penis - pathology
Penis - surgery
Sarcoma - pathology
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Summary:According to the most recent World Health Organization (WHO) guidelines a diagnosis of malignant fibrous histiocytoma (MFH) should be made only for lesions composed of tumor cells without evidence of a specific line of differentiation. This is therefore a diagnosis by exclusion which is why the name of undifferentiated high-grade pleomorphic sarcoma (UPS) should be preferred. Soft tissue sarcomas currently have an incidence in all body regions of approximately 20 cases per 1 million inhabitants per year. Soft tissue tumors of the penis represent approximately 5 % of all penile tumors and the incidence of penile sarcomas is estimated to be approximately 0.6-1 case per 100,000 patients. Only seven cases have so far been reported in the literature. This article describes the case of a 61-year-old Caucasian male who presented with a painless mass sited in the upper part of the corpus cavernosa. An incisional biopsy with a subsequent investigation using an extensive immunohistochemical panel were performed and a high-grade undifferentiated pleomorphic sarcoma or pleomorphic storiform MFH was diagnosed. In addition to the case report a literature review is presented to elaborate the discussion on the differential diagnoses of these kinds of lesions.
ISSN:1432-1963
DOI:10.1007/s00292-015-0036-9