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Malignant fibrous histiocytoma of the penis
According to the most recent World Health Organization (WHO) guidelines a diagnosis of malignant fibrous histiocytoma (MFH) should be made only for lesions composed of tumor cells without evidence of a specific line of differentiation. This is therefore a diagnosis by exclusion which is why the name...
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Published in: | Der Pathologe 2015-07, Vol.36 (4), p.385-388 |
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container_title | Der Pathologe |
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creator | Crisman, G Margiotta, G Calabresi, M Discepoli, S Leocata, P |
description | According to the most recent World Health Organization (WHO) guidelines a diagnosis of malignant fibrous histiocytoma (MFH) should be made only for lesions composed of tumor cells without evidence of a specific line of differentiation. This is therefore a diagnosis by exclusion which is why the name of undifferentiated high-grade pleomorphic sarcoma (UPS) should be preferred. Soft tissue sarcomas currently have an incidence in all body regions of approximately 20 cases per 1 million inhabitants per year. Soft tissue tumors of the penis represent approximately 5 % of all penile tumors and the incidence of penile sarcomas is estimated to be approximately 0.6-1 case per 100,000 patients. Only seven cases have so far been reported in the literature. This article describes the case of a 61-year-old Caucasian male who presented with a painless mass sited in the upper part of the corpus cavernosa. An incisional biopsy with a subsequent investigation using an extensive immunohistochemical panel were performed and a high-grade undifferentiated pleomorphic sarcoma or pleomorphic storiform MFH was diagnosed. In addition to the case report a literature review is presented to elaborate the discussion on the differential diagnoses of these kinds of lesions. |
doi_str_mv | 10.1007/s00292-015-0036-9 |
format | article |
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This is therefore a diagnosis by exclusion which is why the name of undifferentiated high-grade pleomorphic sarcoma (UPS) should be preferred. Soft tissue sarcomas currently have an incidence in all body regions of approximately 20 cases per 1 million inhabitants per year. Soft tissue tumors of the penis represent approximately 5 % of all penile tumors and the incidence of penile sarcomas is estimated to be approximately 0.6-1 case per 100,000 patients. Only seven cases have so far been reported in the literature. This article describes the case of a 61-year-old Caucasian male who presented with a painless mass sited in the upper part of the corpus cavernosa. An incisional biopsy with a subsequent investigation using an extensive immunohistochemical panel were performed and a high-grade undifferentiated pleomorphic sarcoma or pleomorphic storiform MFH was diagnosed. 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In addition to the case report a literature review is presented to elaborate the discussion on the differential diagnoses of these kinds of lesions.</description><subject>Biopsy</subject><subject>Diagnosis, Differential</subject><subject>Guideline Adherence</subject><subject>Histiocytoma, Malignant Fibrous - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Penile Neoplasms - pathology</subject><subject>Penis - pathology</subject><subject>Penis - surgery</subject><subject>Sarcoma - pathology</subject><issn>1432-1963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNo1j0tLAzEURoMgtlZ_gBuZpSDRm9zJnclSii-ouNH1kEwSG5mXk3TRf2_Bujqbw-H7GLsScCcAqvsEILXkIBQHQOL6hC1FiZILTbhg5yl9A4AqpTxjC0mgFKJYsts308WvwQy5CNHO4y4V25hyHNt9HntTjKHIW19Mfojpgp0G0yV_eeSKfT49fqxf-Ob9-XX9sOGTKEXmtbbWgpcaLJLywSpVoydstceKrBKSSkJXhaCl9dK1pXKVC7UrXdW6mnDFbv660zz-7HzKTR9T67vODP4wsBGka02kJR7U66O6s713zTTH3sz75v8g_gJYlU_1</recordid><startdate>201507</startdate><enddate>201507</enddate><creator>Crisman, G</creator><creator>Margiotta, G</creator><creator>Calabresi, M</creator><creator>Discepoli, S</creator><creator>Leocata, P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201507</creationdate><title>Malignant fibrous histiocytoma of the penis</title><author>Crisman, G ; Margiotta, G ; Calabresi, M ; Discepoli, S ; Leocata, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-89bbb0e290b365efb5583e63c9e376b5126463d7ff92be2dc45d7df8d4d7cd863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>ger</language><creationdate>2015</creationdate><topic>Biopsy</topic><topic>Diagnosis, Differential</topic><topic>Guideline Adherence</topic><topic>Histiocytoma, Malignant Fibrous - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Penile Neoplasms - pathology</topic><topic>Penis - pathology</topic><topic>Penis - surgery</topic><topic>Sarcoma - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Crisman, G</creatorcontrib><creatorcontrib>Margiotta, G</creatorcontrib><creatorcontrib>Calabresi, M</creatorcontrib><creatorcontrib>Discepoli, S</creatorcontrib><creatorcontrib>Leocata, P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Der Pathologe</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crisman, G</au><au>Margiotta, G</au><au>Calabresi, M</au><au>Discepoli, S</au><au>Leocata, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant fibrous histiocytoma of the penis</atitle><jtitle>Der Pathologe</jtitle><addtitle>Pathologe</addtitle><date>2015-07</date><risdate>2015</risdate><volume>36</volume><issue>4</issue><spage>385</spage><epage>388</epage><pages>385-388</pages><eissn>1432-1963</eissn><abstract>According to the most recent World Health Organization (WHO) guidelines a diagnosis of malignant fibrous histiocytoma (MFH) should be made only for lesions composed of tumor cells without evidence of a specific line of differentiation. 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ispartof | Der Pathologe, 2015-07, Vol.36 (4), p.385-388 |
issn | 1432-1963 |
language | ger |
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source | Alma/SFX Local Collection |
subjects | Biopsy Diagnosis, Differential Guideline Adherence Histiocytoma, Malignant Fibrous - pathology Humans Male Middle Aged Neoplasm Grading Penile Neoplasms - pathology Penis - pathology Penis - surgery Sarcoma - pathology |
title | Malignant fibrous histiocytoma of the penis |
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