Autoimmune hepatitis: the role of environmental risk factors: a population-based study

Purpose The etiology of autoimmune hepatitis (AIH) likely involves a complex interaction of genetic and environmental factors. We aim to investigate the associations between exposure to putative environmental factors and AIH and to quantify AIH risk in a first-degree relative. Methods We conducted a...

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Bibliographic Details
Published in:Hepatology international 2013-07, Vol.7 (3), p.869-875
Main Authors: Ngu, Jing H., Gearry, Richard B., Frampton, Chris M., Stedman, Catherine A. M.
Format: Article
Language:English
Subjects:
Alcohol
Colorectal Surgery
Hepatology
Medicine
Medicine & Public Health
Original Article
Surgery
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Summary:Purpose The etiology of autoimmune hepatitis (AIH) likely involves a complex interaction of genetic and environmental factors. We aim to investigate the associations between exposure to putative environmental factors and AIH and to quantify AIH risk in a first-degree relative. Methods We conducted a population-based case-control study. Cases were AIH patients who were alive and resided in Canterbury, New Zealand, between 1 July 2011 and 30 June 2012. Controls were randomly selected from the Electoral Roll and were matched 2:1 to each case by age and gender. Self-reporting questionnaires that cover lifestyle factors, childhood factors and family history were used. Results 72 AIH cases and 144 controls were included. We found that exposure to antibiotics within 12 months prior to AIH diagnosis (OR 12.98, 95 % CI 2.49–67.67, p  
ISSN:1936-0533
1936-0541
DOI:10.1007/s12072-013-9448-x