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New simple prognostic score for primary biliary cirrhosis: Albumin-bilirubin score
Background and Aim Serum albumin and bilirubin are the most significant independent prognostic factors to predict hepatic events in patients with primary biliary cirrhosis (PBC). We aimed to investigate the prognostic significance of a new prognostic score, the albumin‐bilirubin (ALBI) score, among...
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| Published in: | Journal of gastroenterology and hepatology 2015-09, Vol.30 (9), p.1391-1396 |
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| container_title | Journal of gastroenterology and hepatology |
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| creator | Chan, Anthony W H Chan, Ronald C K Wong, Grace L H Wong, Vincent W S Choi, Paul C L Chan, Henry L Y To, Ka-Fai |
| description | Background and Aim
Serum albumin and bilirubin are the most significant independent prognostic factors to predict hepatic events in patients with primary biliary cirrhosis (PBC). We aimed to investigate the prognostic significance of a new prognostic score, the albumin‐bilirubin (ALBI) score, among PBC patients.
Methods
In a retrospective longitudinal cohort of 61 Chinese PBC patients with follow‐up period up to 18.3 years, the prognostic performance of the ALBI in prediction of hepatic events was compared with other well‐established prognostic scores: Child–Pugh score, model of end‐stage liver disease, Mayo risk score, Yale, European, and Newcastle models.
Results
Fifteen patients (24.6%) developed hepatic events during follow‐up. The c‐index (0.894) and χ2 by likelihood ratio test (36.34) of the ALBI score were highest in comparison to other models. The ALBI score was the only independent prognostic factor by multivariate analysis and its adjusted hazard ratio of developing hepatic event was 27.8 (P −2.60 to −1.39), and grade 3 (> −1.39) groups. The 2‐, 5‐, and 10‐year event‐free survivals for grade 1, grade 2, and grade 3 groups were 100.0% versus 100.0% versus 57.1%, 100.0% versus 88.5% versus 14.3%, and 100.0% versus 81.7% versus 0.0%, respectively (P |
| doi_str_mv | 10.1111/jgh.12938 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1699493911</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1699493911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4298-c8ade825d4354c1734c23c737c1aa07efea40544537eefaba767de21ad9b6ce23</originalsourceid><addsrcrecordid>eNp1kM1OwzAQhC0EoqVw4AVQjnBIa8d2HHNDiLagCkQF9Gg5zqYY8gN2o8Lbk5LSG3tZafeb0e4gdErwkLQ1elu-DkkkabKH-oQxHBLB4n3UxwnhoaRE9tCR928YY4YFP0S9iAtOZST6aH4P68Db8qOA4MPVy6r2K2sCb2oHQV67dmhL7b6D1BZ204117rX21l8GV0XalLYKNyvXpLbqZMfoINeFh5NtH6Dn8c3T9TScPUxur69moWGRTEKT6AySiGeMcmaIoMxE1AgqDNEaC8hBM8wZ41QA5DrVIhYZRERnMo0NRHSAzjvf9u7PBvxKldYbKApdQd14RWIpmaSSkBa96FDjau8d5Gr7liJYbSJUbYTqN8KWPdvaNmkJ2Y78y6wFRh2wtgV8_--k7ibTP8uwU1i_gq-dQrt3FbcPc7W4n6jH-QvGi3isXugPepKLIA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1699493911</pqid></control><display><type>article</type><title>New simple prognostic score for primary biliary cirrhosis: Albumin-bilirubin score</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Chan, Anthony W H ; Chan, Ronald C K ; Wong, Grace L H ; Wong, Vincent W S ; Choi, Paul C L ; Chan, Henry L Y ; To, Ka-Fai</creator><creatorcontrib>Chan, Anthony W H ; Chan, Ronald C K ; Wong, Grace L H ; Wong, Vincent W S ; Choi, Paul C L ; Chan, Henry L Y ; To, Ka-Fai</creatorcontrib><description>Background and Aim
Serum albumin and bilirubin are the most significant independent prognostic factors to predict hepatic events in patients with primary biliary cirrhosis (PBC). We aimed to investigate the prognostic significance of a new prognostic score, the albumin‐bilirubin (ALBI) score, among PBC patients.
Methods
In a retrospective longitudinal cohort of 61 Chinese PBC patients with follow‐up period up to 18.3 years, the prognostic performance of the ALBI in prediction of hepatic events was compared with other well‐established prognostic scores: Child–Pugh score, model of end‐stage liver disease, Mayo risk score, Yale, European, and Newcastle models.
Results
Fifteen patients (24.6%) developed hepatic events during follow‐up. The c‐index (0.894) and χ2 by likelihood ratio test (36.34) of the ALBI score were highest in comparison to other models. The ALBI score was the only independent prognostic factor by multivariate analysis and its adjusted hazard ratio of developing hepatic event was 27.8 (P < 0.001). There were three prognostically different groups stratified by the ALBI score: ALBI grade 1 (≤ −2.60), grade 2 (> −2.60 to −1.39), and grade 3 (> −1.39) groups. The 2‐, 5‐, and 10‐year event‐free survivals for grade 1, grade 2, and grade 3 groups were 100.0% versus 100.0% versus 57.1%, 100.0% versus 88.5% versus 14.3%, and 100.0% versus 81.7% versus 0.0%, respectively (P < 0.001).
Conclusion
The ALBI score is readily derived from a blood test without using those factors evaluated subjectively or obtained by invasive procedures. It is an independent prognostic factor for PBC patients and provides better/similar prognostic performance compared with other prognostic scores.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.12938</identifier><identifier>PMID: 25753927</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bilirubin - blood ; Biomarkers - blood ; Child-Pugh score ; Cohort Studies ; Diagnostic Techniques, Digestive System ; European model ; Female ; Follow-Up Studies ; hepatic event ; Humans ; Liver Cirrhosis, Biliary - blood ; Liver Cirrhosis, Biliary - diagnosis ; Longitudinal Studies ; Male ; Mayo risk score ; MELD ; Middle Aged ; Multivariate Analysis ; Newcastle model ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Serum Albumin - analysis ; survival ; Yale model</subject><ispartof>Journal of gastroenterology and hepatology, 2015-09, Vol.30 (9), p.1391-1396</ispartof><rights>2015 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd</rights><rights>2015 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4298-c8ade825d4354c1734c23c737c1aa07efea40544537eefaba767de21ad9b6ce23</citedby><cites>FETCH-LOGICAL-c4298-c8ade825d4354c1734c23c737c1aa07efea40544537eefaba767de21ad9b6ce23</cites><orcidid>0000-0002-1771-163X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25753927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, Anthony W H</creatorcontrib><creatorcontrib>Chan, Ronald C K</creatorcontrib><creatorcontrib>Wong, Grace L H</creatorcontrib><creatorcontrib>Wong, Vincent W S</creatorcontrib><creatorcontrib>Choi, Paul C L</creatorcontrib><creatorcontrib>Chan, Henry L Y</creatorcontrib><creatorcontrib>To, Ka-Fai</creatorcontrib><title>New simple prognostic score for primary biliary cirrhosis: Albumin-bilirubin score</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
Serum albumin and bilirubin are the most significant independent prognostic factors to predict hepatic events in patients with primary biliary cirrhosis (PBC). We aimed to investigate the prognostic significance of a new prognostic score, the albumin‐bilirubin (ALBI) score, among PBC patients.
Methods
In a retrospective longitudinal cohort of 61 Chinese PBC patients with follow‐up period up to 18.3 years, the prognostic performance of the ALBI in prediction of hepatic events was compared with other well‐established prognostic scores: Child–Pugh score, model of end‐stage liver disease, Mayo risk score, Yale, European, and Newcastle models.
Results
Fifteen patients (24.6%) developed hepatic events during follow‐up. The c‐index (0.894) and χ2 by likelihood ratio test (36.34) of the ALBI score were highest in comparison to other models. The ALBI score was the only independent prognostic factor by multivariate analysis and its adjusted hazard ratio of developing hepatic event was 27.8 (P < 0.001). There were three prognostically different groups stratified by the ALBI score: ALBI grade 1 (≤ −2.60), grade 2 (> −2.60 to −1.39), and grade 3 (> −1.39) groups. The 2‐, 5‐, and 10‐year event‐free survivals for grade 1, grade 2, and grade 3 groups were 100.0% versus 100.0% versus 57.1%, 100.0% versus 88.5% versus 14.3%, and 100.0% versus 81.7% versus 0.0%, respectively (P < 0.001).
Conclusion
The ALBI score is readily derived from a blood test without using those factors evaluated subjectively or obtained by invasive procedures. It is an independent prognostic factor for PBC patients and provides better/similar prognostic performance compared with other prognostic scores.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bilirubin - blood</subject><subject>Biomarkers - blood</subject><subject>Child-Pugh score</subject><subject>Cohort Studies</subject><subject>Diagnostic Techniques, Digestive System</subject><subject>European model</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>hepatic event</subject><subject>Humans</subject><subject>Liver Cirrhosis, Biliary - blood</subject><subject>Liver Cirrhosis, Biliary - diagnosis</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Mayo risk score</subject><subject>MELD</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Newcastle model</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Serum Albumin - analysis</subject><subject>survival</subject><subject>Yale model</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kM1OwzAQhC0EoqVw4AVQjnBIa8d2HHNDiLagCkQF9Gg5zqYY8gN2o8Lbk5LSG3tZafeb0e4gdErwkLQ1elu-DkkkabKH-oQxHBLB4n3UxwnhoaRE9tCR928YY4YFP0S9iAtOZST6aH4P68Db8qOA4MPVy6r2K2sCb2oHQV67dmhL7b6D1BZ204117rX21l8GV0XalLYKNyvXpLbqZMfoINeFh5NtH6Dn8c3T9TScPUxur69moWGRTEKT6AySiGeMcmaIoMxE1AgqDNEaC8hBM8wZ41QA5DrVIhYZRERnMo0NRHSAzjvf9u7PBvxKldYbKApdQd14RWIpmaSSkBa96FDjau8d5Gr7liJYbSJUbYTqN8KWPdvaNmkJ2Y78y6wFRh2wtgV8_--k7ibTP8uwU1i_gq-dQrt3FbcPc7W4n6jH-QvGi3isXugPepKLIA</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Chan, Anthony W H</creator><creator>Chan, Ronald C K</creator><creator>Wong, Grace L H</creator><creator>Wong, Vincent W S</creator><creator>Choi, Paul C L</creator><creator>Chan, Henry L Y</creator><creator>To, Ka-Fai</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1771-163X</orcidid></search><sort><creationdate>201509</creationdate><title>New simple prognostic score for primary biliary cirrhosis: Albumin-bilirubin score</title><author>Chan, Anthony W H ; Chan, Ronald C K ; Wong, Grace L H ; Wong, Vincent W S ; Choi, Paul C L ; Chan, Henry L Y ; To, Ka-Fai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4298-c8ade825d4354c1734c23c737c1aa07efea40544537eefaba767de21ad9b6ce23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bilirubin - blood</topic><topic>Biomarkers - blood</topic><topic>Child-Pugh score</topic><topic>Cohort Studies</topic><topic>Diagnostic Techniques, Digestive System</topic><topic>European model</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>hepatic event</topic><topic>Humans</topic><topic>Liver Cirrhosis, Biliary - blood</topic><topic>Liver Cirrhosis, Biliary - diagnosis</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Mayo risk score</topic><topic>MELD</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Newcastle model</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Serum Albumin - analysis</topic><topic>survival</topic><topic>Yale model</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, Anthony W H</creatorcontrib><creatorcontrib>Chan, Ronald C K</creatorcontrib><creatorcontrib>Wong, Grace L H</creatorcontrib><creatorcontrib>Wong, Vincent W S</creatorcontrib><creatorcontrib>Choi, Paul C L</creatorcontrib><creatorcontrib>Chan, Henry L Y</creatorcontrib><creatorcontrib>To, Ka-Fai</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, Anthony W H</au><au>Chan, Ronald C K</au><au>Wong, Grace L H</au><au>Wong, Vincent W S</au><au>Choi, Paul C L</au><au>Chan, Henry L Y</au><au>To, Ka-Fai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New simple prognostic score for primary biliary cirrhosis: Albumin-bilirubin score</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2015-09</date><risdate>2015</risdate><volume>30</volume><issue>9</issue><spage>1391</spage><epage>1396</epage><pages>1391-1396</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
Serum albumin and bilirubin are the most significant independent prognostic factors to predict hepatic events in patients with primary biliary cirrhosis (PBC). We aimed to investigate the prognostic significance of a new prognostic score, the albumin‐bilirubin (ALBI) score, among PBC patients.
Methods
In a retrospective longitudinal cohort of 61 Chinese PBC patients with follow‐up period up to 18.3 years, the prognostic performance of the ALBI in prediction of hepatic events was compared with other well‐established prognostic scores: Child–Pugh score, model of end‐stage liver disease, Mayo risk score, Yale, European, and Newcastle models.
Results
Fifteen patients (24.6%) developed hepatic events during follow‐up. The c‐index (0.894) and χ2 by likelihood ratio test (36.34) of the ALBI score were highest in comparison to other models. The ALBI score was the only independent prognostic factor by multivariate analysis and its adjusted hazard ratio of developing hepatic event was 27.8 (P < 0.001). There were three prognostically different groups stratified by the ALBI score: ALBI grade 1 (≤ −2.60), grade 2 (> −2.60 to −1.39), and grade 3 (> −1.39) groups. The 2‐, 5‐, and 10‐year event‐free survivals for grade 1, grade 2, and grade 3 groups were 100.0% versus 100.0% versus 57.1%, 100.0% versus 88.5% versus 14.3%, and 100.0% versus 81.7% versus 0.0%, respectively (P < 0.001).
Conclusion
The ALBI score is readily derived from a blood test without using those factors evaluated subjectively or obtained by invasive procedures. It is an independent prognostic factor for PBC patients and provides better/similar prognostic performance compared with other prognostic scores.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>25753927</pmid><doi>10.1111/jgh.12938</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-1771-163X</orcidid></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Bilirubin - blood Biomarkers - blood Child-Pugh score Cohort Studies Diagnostic Techniques, Digestive System European model Female Follow-Up Studies hepatic event Humans Liver Cirrhosis, Biliary - blood Liver Cirrhosis, Biliary - diagnosis Longitudinal Studies Male Mayo risk score MELD Middle Aged Multivariate Analysis Newcastle model Prognosis Proportional Hazards Models Retrospective Studies Serum Albumin - analysis survival Yale model |
| title | New simple prognostic score for primary biliary cirrhosis: Albumin-bilirubin score |
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