Effects of ginsenosides on impaired performance induced in the rat by scopolamine in a radial-arm maze

The effects of ginsenosides Rg1, Rd and Rb1 on impaired performance induced in the rat by scopolamine were examined in a radial-arm maze. Scopolamine caused a reduction in the number of initial correct responses in the maze. A single IP injection of Rg1, but not Rd or Rb1, prevented the reduction. T...

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Bibliographic Details
Published in:Psychoneuroendocrinology 1995, Vol.20 (6), p.645-653
Main Authors: Yamaguchi, Yoshimasa, Haruta, Kazuhiko, Kobayashi, Hideshi
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain Mapping
Central Nervous System Agents - pharmacology
Cholinergic Fibers - drug effects
Cholinergic system
Dose-Response Relationship, Drug
Ginsenoside
Ginsenosides
Impaired performance
Injections, Intraperitoneal
Male
Maze
Maze Learning - drug effects
Medial septum
Medical sciences
Mental Recall - drug effects
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Orientation - drug effects
Pharmacology. Drug treatments
Rat
Rats
Rats, Sprague-Dawley
Saponins - pharmacology
Scopolamine
Scopolamine - pharmacology
Septum Pellucidum - drug effects
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Summary:The effects of ginsenosides Rg1, Rd and Rb1 on impaired performance induced in the rat by scopolamine were examined in a radial-arm maze. Scopolamine caused a reduction in the number of initial correct responses in the maze. A single IP injection of Rg1, but not Rd or Rb1, prevented the reduction. The inhibition of the reduction in initial correct responses was associated with a bell-shaped dose-response curve for Rg1. A lesion in the medial septum caused spatial learning deficits. Rg1 did not overcome these deficits. It is suggested that cholinergic neurons in the medial septum are involved in the ameliorative effect of Rg1 on impaired performance induced by scopolamine.
ISSN:0306-4530
1873-3360
DOI:10.1016/0306-4530(95)00008-C