Liver transplantation as a definitive treatment for familial hypercholesterolemia: A series of 36 cases

FH is a genetic disorder characterized by an increase in serum LDL and total cholesterol values. The afflicted patients are at increased risk of premature atherosclerosis and myocardial infarction. Different treatment modalities are present, including pharmacological agents and surgical procedures....

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Bibliographic Details
Published in:Pediatric transplantation 2015-09, Vol.19 (6), p.605-611
Main Authors: Mansoorian, Mohsenreza, Kazemi, Kourosh, Nikeghbalian, Saman, Shamsaeefar, Alireza, Mokhtari, Maral, Dehghani, Seyed Mohsen, Bahador, Ali, Salahi, Heshmatollah, Amoozgar, Hamid, Malek Hosseini, Seyed Ali
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child, Preschool
familial hypercholesterolemia
Female
Follow-Up Studies
Humans
Hyperlipoproteinemia Type II - surgery
liver
Liver Transplantation
Male
Postoperative Complications
Retrospective Studies
transplantation
Treatment Outcome
Young Adult
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Summary:FH is a genetic disorder characterized by an increase in serum LDL and total cholesterol values. The afflicted patients are at increased risk of premature atherosclerosis and myocardial infarction. Different treatment modalities are present, including pharmacological agents and surgical procedures. The most effective method of therapy in refractive cases is liver transplantation. Herein, we report our experience on 36 cases of patients with FH undergoing liver transplantation in our center, the main referral center of liver transplantation in Iran. The clinical findings, hospital courses, post‐operative complications, and patient follow‐up are also described.
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.12562