A comparative MRI study of cartilage damage in gout versus rheumatoid arthritis

• Published in: Journal of medical imaging and radiation oncology 2015-08, Vol.59 (4), p.431-435
• Main Authors: Popovich, Ivor, Lee, Arier CL, Doyle, Anthony, McHaffie, Alexandra, Clarke, Andrew, Reeves, Quentin, Dalbeth, Nicola, McQueen, Fiona M
• Format: Article
• Language: English
• Subjects: Adult; Aged; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - pathology; cartilage; Cartilage - pathology; Cartilage Diseases - etiology; Cartilage Diseases - pathology; Female; gout; Gout - complications; Gout - pathology; Humans; Magnetic Resonance Imaging - methods; Male; Middle Aged; MRI; NMR; Nuclear magnetic resonance; Reproducibility of Results; Rheumatism; Rheumatoid arthritis; Sensitivity and Specificity; Wrist Joint - pathology
• ISSN: 1754-9477; 1754-9485
• DOI: 10.1111/1754-9485.12306

Introduction Magnetic resonance imaging (MRI) is useful for detecting joint inflammation and damage in the inflammatory arthropathies. This study aimed to investigate MRI cartilage damage and its associations with joint inflammation in patients with gout compared with a group with rheumatoid arthritis (RA). Methods Forty patients with gout and 38 with seropositive RA underwent 3T‐MRI of the wrist with assessment of cartilage damage at six carpal sites, using established scoring systems. Synovitis and bone oedema (BME) were graded according to Rheumatoid Arthritis MRI Scoring System criteria. Cartilage damage was compared between the groups adjusting for synovitis and disease duration using logistic regression analysis. Results Compared with RA, there were fewer sites of cartilage damage and lower total damage scores in the gout group (P = 0.02 and 0.003), adjusting for their longer disease duration and lesser degree of synovitis. Cartilage damage was strongly associated with synovitis in both conditions (R = 0.59, P