The Molecular Epidemiology Of Human Immunodeficiency Virus Type 1 In Edinburgh

Human immunodeficiency virus (HIV) type 1 sequences obtained from HIV-infected persons in different risk groups in Edinburgh were studied to determine the number and origin of virus variants and patterns of virus transmission. Phylogenetic analysis revealed that 12 of 14 hemophiliac patients who had...

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Bibliographic Details
Published in:The Journal of infectious diseases 1995-01, Vol.171 (1), p.45-53
Main Authors: Holmes, Edward C., Zhang, Lin Qi, Robertson, Pamela, Cleland, Alexander, Harvey, Elizabeth, Simmonds, Peter, Leigh Brown, Andrew J.
Format: Article
Language:English
Subjects:
AIDS
Base Sequence
Biological and medical sciences
Cohort Studies
Disease transmission
DNA, Viral - genetics
Drug Contamination
env genes
Epidemiology
Evolution
Factor VIII - adverse effects
Female
Fundamental and applied biological sciences. Psychology
gag Gene Products, Human Immunodeficiency Virus
Gene Products, gag - genetics
Genetic Variation
Hemophilia A - complications
HIV
HIV 1
HIV Antigens - genetics
HIV Envelope Protein gp120 - genetics
HIV Infections - epidemiology
HIV Infections - transmission
HIV Infections - virology
HIV-1 - classification
HIV-1 - genetics
human immunodeficiency virus 1
Humans
Infections
Major Articles
Male
Microbiology
Molecular Epidemiology
Molecular Sequence Data
Peptide Fragments - genetics
Phylogenetics
Phylogeny
Risk Factors
Scotland - epidemiology
Sexual Behavior
Substance Abuse, Intravenous - complications
Viral Proteins
Virology
Viruses
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Description
Summary:Human immunodeficiency virus (HIV) type 1 sequences obtained from HIV-infected persons in different risk groups in Edinburgh were studied to determine the number and origin of virus variants and patterns of virus transmission. Phylogenetic analysis revealed that 12 of 14 hemophiliac patients who had been exposed to a single common batch of factor VIII had closely related gag gene sequences. Sequences from intravenous drug users and patients infected through heterosexual contact formed another distinct group, and 2 other hemophiliacs formed a third group. However, epidemiologic relationships inferred from analysis of the V3 region of the env gene were less conclusive, especially when the V3 loop was taken in isolation. This appears to be due to the length of time since infection and the action of selection, which has favored the independent appearance of similar V3 loop variants.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/171.1.45