Association of Bone Mineral Density and Sex Hormone Levels with Osteoarthritis of the Hand and Knee in Premenopausal Women

Mechanical stress on the cartilage and metabolic and/or hormonal influences have been suggested as possible etiologic factors for osteoarthritis. This paper reports findings from data collected in 1992 that were used to examine associations between osteoarthritis and risk factors in 573 Caucasian wo...

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Bibliographic Details
Published in:American journal of epidemiology 1996-01, Vol.143 (1), p.38-47
Main Authors: Sowers, MaryFran, Hochberg, Marc, Crabbe, Jeffrey P., Muhich, Anthony, Crutchfield, Mary, Updike, Sharon
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Bone Density
Cross-Sectional Studies
Diseases of the osteoarticular system
Estradiol - blood
estrogens
Female
hand
Hand - diagnostic imaging
Humans
knee
Knee Joint - diagnostic imaging
Longitudinal Studies
Medical sciences
Michigan - epidemiology
Middle Aged
Osteoarthritis
Osteoarthritis - blood
Osteoarthritis - diagnostic imaging
Osteoarthritis - epidemiology
premenopause
Premenopause - blood
Premenopause - physiology
Prevalence
Radiography
Regression Analysis
Risk Factors
testosterone
Testosterone - blood
women
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Summary:Mechanical stress on the cartilage and metabolic and/or hormonal influences have been suggested as possible etiologic factors for osteoarthritis. This paper reports findings from data collected in 1992 that were used to examine associations between osteoarthritis and risk factors in 573 Caucasian women aged 24–45 years from the Michigan Bone Health Study. Radiographs of the dominant hand and both knees were evaluated using the Kellgren and Lawrence grading scale. The prevalence of osteoarthritis (grade 2 or higher) in this population was 2.8% for hands and 3.6% for knees. Using polytomous multiple logistic regression, the authors found older age, increasing bone mineral density, and decreasing testosterone levels to be significantly associated with increasing hand scores. Older age and hand injury were significantly associated with grades of 2 or higher. Increasing osteoarthritis knee scores were associated with older age, increasing bone density, increasing body mass index, and current use of hormone replacement therapy. A knee grade of 2 or higher was associated with increasing estradiol levels, knee injury, and higher blood pressure. This study indicates that age, bone density, and injury are risk factors common to the development of hand and knee osteoarthritis in this non-elderly female population. Am J Epidemiol 1996;143:38–47
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a008655