Modulation of Pseudomonas aeruginosa adherence to collagen type Iand type II by carbohydrates

This study was undertaken to examine if receptor recognizing saccharides may be involved in the adherence of Pseudomonas aeruginosa to collagen type I and type II. We performed an adherence inhibition assay: cells of individual P. aeruginosa isolates attached to immobilized collagen type I or type I...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology 1995-01, Vol.12 (3-4), p.187-194
Main Authors: Stepinska, M, Trafny, E A
Format: Article
Language:English
Subjects:
Pseudomonas aeruginosa
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Summary:This study was undertaken to examine if receptor recognizing saccharides may be involved in the adherence of Pseudomonas aeruginosa to collagen type I and type II. We performed an adherence inhibition assay: cells of individual P. aeruginosa isolates attached to immobilized collagen type I or type II in the presence of monosaccharides, which could serve as blockers of bacterial receptors. Bacterial binding to collagen type I molecules was inhibited to the highest degree by sugar composition d-galactose/d-mannose/N-acetylneuraminic acid (5:5:1), whereas attachment of P. aeruginosa to collagen type II was inhibited by composition d-glucose/d-galactose (1:1). The same strains which were sensitive to inhibition of binding to collagen type II by both collagen types, were also sensitive to blocking by composition d-glucose/d-galactose. It suggests that saccharides play a role in adherence of P.aeruginosa to collagen type I and type II, and a common receptor for both types of collagen may be available on the surface of P. aeruginosa cells.
ISSN:0928-8244