Effects of sodium bicarbonate correction of metabolic acidosis on regional tissue oxygenation in very low birth weight neonates

• Published in: Journal of perinatology 2015-08, Vol.35 (8), p.601-606
• Main Authors: Mintzer, J P, Parvez, B, Alpan, G, LaGamma, E F
• Format: Article
• Language: English
• Subjects: 692/1807/244; 692/700/139/1735; 9/10; Acidosis; Acidosis - drug therapy; Analysis; Birth Weight; Blood pressure; Creatinine; Drug therapy; Gestational Age; Health aspects; Heart rate; Hematocrit; Humans; Infant, Extremely Premature; Infant, Newborn; Infant, Very Low Birth Weight; Infants (Premature); Intensive Care, Neonatal; Kidneys; Lactic acid; Low birth weight; Medicine; Medicine & Public Health; Metabolic acidosis; Metabolism; Monitoring, Physiologic - methods; Neonates; Newborn babies; original-article; Oximetry; Oximetry - methods; Oxygen; Oxygen consumption; Oxygen Consumption - drug effects; Oxygen content; Oxygenation; Pediatric Surgery; Pediatrics; pH effects; Prospective Studies; Sodium; Sodium bicarbonate; Sodium Bicarbonate - therapeutic use; Tissues; Urea; Weight
• ISSN: 0743-8346; 1476-5543
• DOI: 10.1038/jp.2015.37

Objective: To determine the effects of sodium bicarbonate (NaHCO 3 ) correction of metabolic acidosis on cardiopulmonary, laboratory, and cerebral, renal and splanchnic regional oxygen saturation (rSO 2 ) and fractional tissue oxygen extraction (FTOE) in extremely premature neonates during the first postnatal week. Study Design: Observational cohort data were collected from 500 to 1250 g neonates who received NaHCO 3 'half' corrections (0.3 * Weight (kg) * Base Deficit (mmol l −1 )) for presumed renal losses. Result: Twelve subjects with normal blood pressure and heart rate received 17 NaHCO 3 corrections. Mean (±s.d.) gestational age was 27±2 week and birth weight was 912±157 g. NaHCO 3 corrections provided a mean (±s.d.) 4.5±1.0 ml kg −1 fluid bolus, shifted mean (±s.d.) base deficit from 7.6±1.8 to 3.4±2.1 mmol l −1 ( P