The effect of gliquidone on KATP channels in pancreatic β-cells, cardiomyocytes, and vascular smooth muscle cells

Highlights • Among drugs tested, gliquidone had moderate affinity to β-cells. • Gliquidone had low affinity to cardiomyocytes and VSMCs. • Thus, gliquidone is a highly selective SUR secretagogue to β-cells.

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Bibliographic Details
Published in:Diabetes research and clinical practice 2015-08, Vol.109 (2), p.334-339
Main Authors: Liu, Shu-Yi, Tian, Hao-Min, Liao, Da-Qing, Chen, Yan-Fang, Gou, Zhong-Ping, Xie, Xiao-Ying, Li, Xiu-Jun
Format: Article
Language:English
Subjects:
Animals
ATP-sensitive potassium channel
Cardiomyocyte
Cell Line
Cricetinae
Endocrinology & Metabolism
Gliquidone
HIT-T15 cell
Insulin-Secreting Cells - cytology
Insulin-Secreting Cells - drug effects
Insulin-Secreting Cells - metabolism
KATP Channels - drug effects
KATP Channels - metabolism
Male
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - metabolism
Myocytes, Cardiac - cytology
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - metabolism
Patch clamp technique
Rats
Rats, Sprague-Dawley
Sulfonylurea Compounds - pharmacology
Sulfonylurea Receptors
Vascular smooth muscle cell
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Description
Summary:Highlights • Among drugs tested, gliquidone had moderate affinity to β-cells. • Gliquidone had low affinity to cardiomyocytes and VSMCs. • Thus, gliquidone is a highly selective SUR secretagogue to β-cells.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2015.05.036