Cardiovascular autonomic tone relation to metabolic parameters and hsCRP in normoglycemia and prediabetes

Abstract Aims The aim of the study was to evaluate cardiovascular autonomic function (CAF) at different stages of obesity and in the presence of metabolic syndrome (MetS), and its association with metabolic parameters and hsCRP in subjects with normal glucose tolerance (NGT) and prediabetes. Methods...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2015-08, Vol.109 (2), p.262-270
Main Authors: Dimova, Rumyana, Tankova, Tsvetalina, Chakarova, Nevena, Groseva, Greta, Dakovska, Lilia
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Autonomic Nervous System - physiopathology
Blood Glucose - metabolism
Blood Pressure
Body Composition
CAF
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - physiopathology
Cardiovascular risk
Cross-Sectional Studies
Endocrinology & Metabolism
Female
Humans
Male
Metabolic Syndrome - blood
Metabolic Syndrome - complications
Middle Aged
NGT
Prediabetes
Prediabetic State - blood
Risk Factors
Young Adult
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Summary:Abstract Aims The aim of the study was to evaluate cardiovascular autonomic function (CAF) at different stages of obesity and in the presence of metabolic syndrome (MetS), and its association with metabolic parameters and hsCRP in subjects with normal glucose tolerance (NGT) and prediabetes. Methods A total of 259 subjects (mean age 47.1 ± 14.6 years, mean BMI 31.4 ± 8.1 kg/m2 ), divided in 2 groups: NGT and prediabetes, and subdivided according to glucose tolerance, BMI and MetS, were enrolled. Anthropometric indices, glucose tolerance, blood pressure, serum lipids and hsCRP were measured. Body composition was estimated by impedance analysis. CAF was assessed by ANX-3.0 method. Results Sympathetic and parasympathetic activity were decreased in severe obesity and MetS as compared to controls in NGT. Negative correlation was observed between sympathetic and parasympathetic tone and BMI, waist circumference, total body fat, visceral fat area (VFA), blood pressure, total and LDL cholesterol, and hsCRP in NGT; and VFA, HbA1c and glycemia in prediabetes. Conclusion Obesity and MetS seem to be associated with CAF deterioration, and metabolic parameters and hsCRP correlate with CAF and probably increase cardiovascular risk in NGT, whilst VFA, HbA1c and glycemia significantly influence CAF alterations in prediabetes.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2015.05.024