Determination of HCH and DDT in finger-prick whole blood dried on filter paper and its field application for monitoring concentrations in blood

The organochlorine insecticides HCH and DDT have been extensively used in India for the control of vector borne diseases. However due to their chemical nature they became major environmental pollutants. Whole blood concentrations are preferred for the assessment of the persistence of HCH and DDT in...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1996-01, Vol.56 (1), p.50-57
Main Authors: Dua, V.K. (Malaria Research Centre, Hardwar, India.), Pant, C.S, Sharma, V.P, Pathak, G.K
Format: Article
Language:English
Subjects:
Aldrin - blood
Biological and medical sciences
BLOOD
Blood Chemical Analysis
Chromatography, Gas
DDT
DDT - blood
Dichlorodiphenyl Dichloroethylene - blood
HCH
Humans
INDE
INDIA
Insecticides - metabolism
Medical sciences
Occupational Exposure
Pesticides, fertilizers and other agrochemicals toxicology
Reference Standards
SANG
SANGRE
Stereoisomerism
Toxicology
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Summary:The organochlorine insecticides HCH and DDT have been extensively used in India for the control of vector borne diseases. However due to their chemical nature they became major environmental pollutants. Whole blood concentrations are preferred for the assessment of the persistence of HCH and DDT in the general population. We present a method for the assay of HCH isomers and DDT metabolites in whole blood samples taken by finger prick and dried on filter paper. This method has been applied for finding HCH and DDT level in whole blood during Ardh Kumbh congregation held at Hardwar in 1992 where these insecticides were extensively used for the control of mosquitoes and house flies.
ISSN:0007-4861
1432-0800
DOI:10.1007/s001289900008