Urinary excretion of alkylphosphates in the general population (Italy)

• Published in: The Science of the total environment 1996-01, Vol.177 (1), p.37-41
• Main Authors: Aprea, Cristina, Sciarra, Gianfranco, Orsi, Daniela, Boccalon, Pierpaolo, Sartorelli, Pietro, Sartorelli, Emilio
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Analysis of Variance; Biological and medical sciences; Biological monitoring; Environmental Pollution; Female; Food Contamination; General population; Humans; Italy; Male; Medical sciences; Middle Aged; Organophosphates - metabolism; Organophosphates - urine; Organophosphorus insecticides; Organothiophosphates - urine; Pesticides, fertilizers and other agrochemicals toxicology; Software; Surveys and Questionnaires; Toxicology; Urinary alkylphosphates
• ISSN: 0048-9697; 1879-1026
• DOI: 10.1016/0048-9697(95)04857-X

Xenobiotic residues and their metabolites in biological fluids of the general population are an important indicator of exposure to toxic substances dispersed in the environment. Urine samples collected from 124 subjects living in SW Tuscany, Italy were analyzed for alkylphosphates (dimethylphosphate, dimethylthiophosphate, dimethyldithiophosphate, diethylphosphate, diethylthiophosphate, diethyldithiophosphate), aspecific metabolites of organophosphorus insecticides. The compound most frequently found was dimethylthiophosphate which was detectable in 99% of the subjects analyzed, with a geometric mean of 70.7 nmol/g creatinine. The other substances were found in the following percentages of our population, at the following mean concentrations: dimethylphosphate, 87%, 62.8 nmol/g creat.; dimethyldithiophosphate, 48%, 21.1 nmol/g creat.; diethylphosphate, 81%, 27.4 nmol/g creat.; diethylthiophosphate, 73%, 22.8 nmol/g creat.; diethyldithiophosphate, 7%, 13.7 nmol/g creatinine. Subjects eating food (fruit, meat, vegetables) that was not their own produce showed higher urinary concentrations of nearly all the compounds. The other variables considered (sex, age, residence, alcohol, smoking, sampling period) seem to affect the percentages of positive values of the various substances but to different degrees. Age and source of foods were the most important variables for dimethylthiophosphate excretion when mean values were analyzed by Student's t-test and analysis of variance (ANOVA).