Ligand-Accelerated Iron- and Cobalt-Catalyzed Cross-Coupling Reactions between N-Heteroaryl Halides and Aryl Magnesium Reagents

Quinoline and isoquinoline dramatically increase the rate and yield of Fe‐ and Co‐catalyzed cross‐coupling reactions. This new catalytic process extends the scope of such cross‐coupling reactions to include complex functional groups and allows heteroaryl–heteroaryl bond formation to occur.

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-04, Vol.52 (18), p.4945-4949
Main Authors: Kuzmina, Olesya M., Steib, Andreas K., Markiewicz, John T., Flubacher, Dietmar, Knochel, Paul
Format: Article
Language:English
Subjects:
Aromatic compounds
Bonding
Catalysis
cobalt
Cobalt - chemistry
cross-coupling
Cyclization
Functional groups
Halides
Iron
Iron - chemistry
isoquinoline
Isoquinolines - chemistry
Ligands
Magnesium
pyridine
Quinoline
Quinolines - chemistry
Transition Elements - chemistry
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Description
Summary:Quinoline and isoquinoline dramatically increase the rate and yield of Fe‐ and Co‐catalyzed cross‐coupling reactions. This new catalytic process extends the scope of such cross‐coupling reactions to include complex functional groups and allows heteroaryl–heteroaryl bond formation to occur.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201210235