The Importance of Additive and Non-Additive Mutational Effects in Protein Engineering

Additive or non‐additive, that is the question: The increasing awareness of non‐additive cooperative mutational effects in protein engineering is currently providing new theoretical and practical insights. In particular, the directed evolution of stereoselective enzymes as catalysts in organic chemi...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-03, Vol.52 (10), p.2658-2666
Main Author: Reetz, Manfred T.
Format: Article
Language:English
Subjects:
Additives
Biotechnology
Catalysis
Catalysts
directed evolution
Enzymes
Evolution
Hydrogen Bonding
Models, Molecular
Molecular Structure
Mutation
mutational additivity
mutational non-additivity
Organic chemistry
Protein Engineering - trends
Proteins
saturation mutagenesis
Thermodynamics
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Summary:Additive or non‐additive, that is the question: The increasing awareness of non‐additive cooperative mutational effects in protein engineering is currently providing new theoretical and practical insights. In particular, the directed evolution of stereoselective enzymes as catalysts in organic chemistry and biotechnology profits from this intriguing development.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201207842