PET Imaging of Bacterial Infections with Fluorine-18-Labeled Maltohexaose

A positron emission tomography (PET) tracer composed of 18F‐labeled maltohexaose (MH18F) can image bacteria in vivo with a sensitivity and specificity that are orders of magnitude higher than those of fluorodeoxyglucose (18FDG). MH18F can detect early‐stage infections composed of as few as 105 E. co...

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Bibliographic Details
Published in:Angewandte Chemie 2014-12, Vol.126 (51), p.14320-14325
Main Authors: Ning, Xinghai, Seo, Wonewoo, Lee, Seungjun, Takemiya, Kiyoko, Rafi, Mohammad, Feng, Xuli, Weiss, Daiana, Wang, Xiaojian, Williams, Larry, Camp, Vernon M., Eugene, Malveaux, Taylor, W. Robert, Goodman, Mark, Murthy, Niren
Format: Article
Language:English
Subjects:
Bacteria
Bacterial infections
Bakterielle Infektionen
Chemistry
Diagnosis
Drug resistance
Drugs
Imaging
Infections
Maltodextrin-Transporter
Maltohexaose
Positron emission
Positronenemissionstomographie
Radiochemie
Tomography
Tracers
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Summary:A positron emission tomography (PET) tracer composed of 18F‐labeled maltohexaose (MH18F) can image bacteria in vivo with a sensitivity and specificity that are orders of magnitude higher than those of fluorodeoxyglucose (18FDG). MH18F can detect early‐stage infections composed of as few as 105 E. coli colony‐forming units (CFUs), and can identify drug resistance in bacteria in vivo. MH18F has the potential to improve the diagnosis of bacterial infections given its unique combination of high specificity and sensitivity for bacteria. Höchst sensibel: Ein Tracer für die Positronenemissionstomographie (PET) bestehend aus 18F‐markierter Maltohexaose (MH18F) bildet Bakterien in vivo mit um ein vielfaches höherer Empfindlichkeit und Genauigkeit ab als Fluordesoxyglucose. MH18F kann Infektionen im Anfangsstadium mit gerade einmal 105 koloniebildenden E.‐coli‐Einheiten detektieren und Wirkstoffresistenzen von Bakterien in vivo bestimmen.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201408533