A drug formulation using an alginate hydrogel matrix for efficient oral delivery of the manganese porphyrin-based superoxide dismutase mimic

In order for patients to avail of the therapeutic benefits of antioxidant drugs efficiently and conveniently, a robust oral delivery system needs to be developed. However, a common problem in oral drug delivery is ensuring that the drug remains functionally intact even after it has passed through th...

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Bibliographic Details
Published in:Biomaterials science 2015-06, Vol.3 (6), p.861-869
Main Authors: Aikawa, T, Ito, S, Shinohara, M, Kaneko, M, Kondo, T, Yuasa, M
Format: Article
Language:English
Subjects:
Administration, Oral
Alginates
Alginates - chemistry
Animals
Antioxidants - administration & dosage
Antioxidants - chemistry
Chemistry, Pharmaceutical
Drug Delivery Systems
Drugs
Formulations
Glucuronic Acid - chemistry
Hexuronic Acids - chemistry
Humans
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Liposomes
Manganese
Manganese - chemistry
Metalloporphyrins - administration & dosage
Metalloporphyrins - chemistry
Mice
Patients
Sod
Superoxide dismutase
Superoxide Dismutase - administration & dosage
Superoxide Dismutase - chemistry
Superoxide Dismutase - metabolism
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Summary:In order for patients to avail of the therapeutic benefits of antioxidant drugs efficiently and conveniently, a robust oral delivery system needs to be developed. However, a common problem in oral drug delivery is ensuring that the drug remains functionally intact even after it has passed through the acidic environment of the gastrointestinal (GI) tract. To protect drugs within the GI environment, we formulated a design based on encapsulating liposomal drugs by using an alginate matrix as a carrier. The liposomal drug was composed of manganese porphyrin (Mn-por), which has been developed as a mimic of superoxide dismutase (SOD), as the therapeutic agent based on the antioxidative effect, namely superoxide (O2˙(-)) inhibitory activity. A cytochrome c assay revealed that the O2˙(-) inhibitory activity of Mn-por could be maintained even after treatment with simulated gastric and intestinal fluids. We demonstrated that oral administration of the formulated drug significantly inhibited the growth of transplanted tumors in mice. The drug formulation presented in this study would be a good candidate for orally available systems, which can effectively deliver SOD mimics.
ISSN:2047-4830
2047-4849
DOI:10.1039/c5bm00056d