A naphthalene diimide dyad for fluorescence switch-on detection of G-quadruplexes

A non-fluorescent naphthalene diimide (NDI) dimer, conjugating red and blue NDI dyes, becomes red/NIR emitting upon G-quadruplex binding. The fluorescence lifetime which is significantly different for the complexes, the G-quadruplex/dimer and the weakly emitting ds-DNA/dimer is the key feature for t...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-06, Vol.51 (44), p.9105-9108
Main Authors: Doria, F, Oppi, A, Manoli, F, Botti, S, Kandoth, N, Grande, V, Manet, I, Freccero, M
Format: Article
Language:English
Subjects:
Binding
Coloring Agents - chemistry
Diimide
Dimerization
Dimers
DNA - chemistry
Dyes
Emittance
Fluorescence
G-Quadruplexes
Imides - chemistry
Inspection
Naphthalene
Naphthalenes - chemistry
Nondestructive testing
Spectrometry, Fluorescence
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Description
Summary:A non-fluorescent naphthalene diimide (NDI) dimer, conjugating red and blue NDI dyes, becomes red/NIR emitting upon G-quadruplex binding. The fluorescence lifetime which is significantly different for the complexes, the G-quadruplex/dimer and the weakly emitting ds-DNA/dimer is the key feature for the development of new rationally engineered G-quadruplex sensors.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc01536g