CH Bond Functionalization through Intramolecular Hydride Transfer

Known for over a century, reactions that involve intramolecular hydride‐transfer events have experienced a recent resurgence. Undoubtedly responsible for the increased interest in this research area is the realization that hydride shifts represent an attractive avenue for CH bond functionalization....

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2014-05, Vol.53 (20), p.5010-5036
Main Authors: Haibach, Michael C., Seidel, Daniel
Format: Article
Language:English
Subjects:
asymmetric catalysis
Bonding
cascade reactions
CH functionalization
hydride transfer
Hydrides
Hydrogen bonds
redox-neutral reactions
Sustainable development
Transformations
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Summary:Known for over a century, reactions that involve intramolecular hydride‐transfer events have experienced a recent resurgence. Undoubtedly responsible for the increased interest in this research area is the realization that hydride shifts represent an attractive avenue for CH bond functionalization. The redox‐neutral nature of these complexity‐enhancing transformations makes them ideal for sustainable reaction development. This Review summarizes recent progress in this field while highlighting key historical contributions. Known for over a century, reactions based on intramolecular hydride transfer have experienced a recent resurgence. Hydride shifts represent an attractive avenue for CH bond functionalization and the redox‐neutral nature of these transformations makes them ideal for the development of sustainable reactions. This Review summarizes recent progress in this field and highlights key historical contributions.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201306489