Free-Standing Gold-Nanoparticle Monolayer Film Fabricated by Protein Self-Assembly of α-Synuclein

Free‐standing nanoparticle films are of great importance for developing future nano‐electronic devices. We introduce a protein‐based fabrication strategy of free‐standing nanoparticle monolayer films. α‐Synuclein, an amyloidogenic protein, was utilized to yield a tightly packed gold‐nanoparticle mon...

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Bibliographic Details
Published in:Angewandte Chemie 2015-04, Vol.127 (15), p.4654-4659
Main Authors: Lee, Junghee, Bhak, Ghibom, Lee, Ji-Hye, Park, Woohyun, Lee, Minwoo, Lee, Daekyun, Jeon, Noo Li, Jeong, Dae H., Char, Kookheon, Paik, Seung R.
Format: Article
Language:English
Subjects:
Contact
Devices
Dünne Filme
Microspheres
Monolayers
Nanopartikel
Nanostructure
Protein-Protein-Wechselwirkungen
Proteins
Selbstorganisation
Self assembly
Sensors
Strategy
Supramolekulare Chemie
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Summary:Free‐standing nanoparticle films are of great importance for developing future nano‐electronic devices. We introduce a protein‐based fabrication strategy of free‐standing nanoparticle monolayer films. α‐Synuclein, an amyloidogenic protein, was utilized to yield a tightly packed gold‐nanoparticle monolayer film interconnected by protein β‐sheet interactions. Owing to the stable protein–protein interaction, the film was successfully expanded to a 4‐inch diameter sheet, which has not been achieved with any other free‐standing nanoparticle monolayers. The film was flexible in solution, so it formed a conformal contact, surrounding even microspheres. Additionally, the monolayer film was readily patterned at micrometer‐scale and thus unprecedented double‐component nanoparticle films were fabricated. Therefore, the free‐floating gold‐nanoparticle monolayer sheets with these properties could make the film useful for the development of bio‐integrated nano‐devices and high‐performance sensors. Film‐Produzent: Proteinbasierte freitragende Goldnanopartikel‐Monoschichten entstehen durch Selbstorganisation der α‐Synuclein‐Proteine auf der Nanopartikeloberfläche. Mit den Filmen können bis zu 10 cm große Wafer beschichtet werden. Durch ihre Elastizität in Lösungsmitteln lassen sich die Filme auf gebogene Oberflächen aufziehen. Auch freie gelochte Blätter und ein Film aus Nanopartikeln mit zweierlei Größe wurden hergestellt.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201412461