Glucose selective surface plasmon resonance-based bis-boronic acid sensor

Saccharides - a versatile class of biologically important molecules - are involved in a variety of physiological and pathological processes, but their detection and quantification is challenging. Herein, surface plasmon resonance and self-assembled monolayers on gold generated from bis-boronic acid...

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Bibliographic Details
Published in:Analyst (London) 2013-12, Vol.138 (23), p.7140-7145
Main Authors: Stephenson-Brown, Alex, Wang, Hui-Chen, Iqbal, Parvez, Preece, Jon A, Long, Yitao, Fossey, John S, James, Tony D, Mendes, Paula M
Format: Article
Language:English
Subjects:
Affinity
Bearing
Binding Sites
Boronic Acids - chemistry
Glucose
Glucose - chemistry
Gold
Photoelectron Spectroscopy
Plasmons
Saccharides
Selectivity
Surface Plasmon Resonance - instrumentation
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Summary:Saccharides - a versatile class of biologically important molecules - are involved in a variety of physiological and pathological processes, but their detection and quantification is challenging. Herein, surface plasmon resonance and self-assembled monolayers on gold generated from bis-boronic acid bearing a thioctic acid moiety, whose intramolecular distance between the boronic acid moieties is well defined, are shown to detect d-glucose with high selectivity, demonstrating a higher affinity than other saccharides probed, namely d-galactose, d-fructose and d-mannose.
ISSN:0003-2654
1364-5528
DOI:10.1039/c3an01233f