[beta]-Hairpin Peptides: Heme Binding, Catalysis, and Structure in Detergent Micelles

Autonomously folded designed [beta]-hairpin peptides in detergent micelles show peroxidase activity with heme binding. Aromatic-aromatic cross-strand packing interactions that stabilize [beta]-hairpin structures in solution are not strictly required for the structure and activity of a [beta]-hairpin...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-06, Vol.52 (25), p.6430-6434
Main Authors: Mahajan, Mukesh, Bhattacharjya, Surajit
Format: Article
Language:English
Subjects:
Binding
Catalysis
Detergents
Micelles
Peptides
Peroxidase
Online Access:Get full text
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Description
Summary:Autonomously folded designed [beta]-hairpin peptides in detergent micelles show peroxidase activity with heme binding. Aromatic-aromatic cross-strand packing interactions that stabilize [beta]-hairpin structures in solution are not strictly required for the structure and activity of a [beta]-hairpin folded in a micelle environment.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201300241