Sandmeyer Trifluoromethylation of Arenediazonium Tetrafluoroborates

Copper capabilities: Diazonium salts are converted into the corresponding trifluoromethyl derivatives in the presence of a trifluoromethyl–copper complex generated in situ from CuSCN and the inexpensive, easy‐to‐use trifluoromethylating reagent Me3Si‐CF3 (see scheme). This Sandmeyer‐type reaction al...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-07, Vol.52 (31), p.7972-7975
Main Authors: Danoun, Grégory, Bayarmagnai, Bilguun, Grünberg, Matthias F., Gooßen, Lukas J.
Format: Article
Language:English
Subjects:
AMINES
Aromatic compounds
Borates - chemistry
CONVERTERS
Coordination Complexes - chemistry
Copper
Copper - chemistry
Copper converters
Derivatives
Diazonium Compounds - chemistry
diazonium salts
FABRICATION
Fluorine - chemistry
Methylation
Sandmeyer reaction
Synthesis
trifluoromethylation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Copper capabilities: Diazonium salts are converted into the corresponding trifluoromethyl derivatives in the presence of a trifluoromethyl–copper complex generated in situ from CuSCN and the inexpensive, easy‐to‐use trifluoromethylating reagent Me3Si‐CF3 (see scheme). This Sandmeyer‐type reaction allows the straightforward synthesis of trifluoromethylated arenes and heteroarenes from the corresponding amines.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201304276