Reaction Discovery by Using a Sandwich Immunoassay

Mmm, a reaction sandwich…︁ Using an immunoassay‐based technique able to monitor any kind of cross‐coupling reaction, a systematic and rapid evaluation of a large panel of random reactions was carried out. This approach led to the discovery of two new copper‐promoted reactions: a desulfurization reac...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-06, Vol.51 (25), p.6144-6148
Main Authors: Quinton, Julia, Kolodych, Sergii, Chaumonet, Manon, Bevilacqua, Valentina, Nevers, Marie-Claire, Volland, Hervé, Gabillet, Sandra, Thuéry, Pierre, Créminon, Christophe, Taran, Frédéric
Format: Article
Language:English
Subjects:
Alkynes
Aminobenzoates - chemistry
Azoles - chemistry
copper
Copper - chemistry
Derivatives
Desulfurizing
high-throughput screening
Immunoassay
immunoassays
Molecular Structure
Monitors
Oxygen - chemistry
Panels
reaction discovery
Thioureas
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Summary:Mmm, a reaction sandwich…︁ Using an immunoassay‐based technique able to monitor any kind of cross‐coupling reaction, a systematic and rapid evaluation of a large panel of random reactions was carried out. This approach led to the discovery of two new copper‐promoted reactions: a desulfurization reaction of thioureas leading to isoureas and a cyclization reaction leading to thiazole derivatives from alkynes and N‐hydroxy thioureas.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201201451